Glucose regulates insulin gene transcription by hyperacetylation of histone h4.
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Epigenetics: a molecular link between environmental factors and type 2 diabetesHistone deacetylases as targets for treatment of multiple diseasesTranslational implications of the β-cell epigenome in diabetes mellitusThe transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domainsHistone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic childrenGlucose regulation of insulin gene transcription and pre-mRNA processing in human islets.Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription.Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation.Chronic ethanol consumption inhibits glucokinase transcriptional activity by Atf3 and triggers metabolic syndrome in vivoDietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases.In vivo pancreatic β-cell-specific expression of antiaging gene Klotho: a novel approach for preserving β-cells in type 2 diabetesAdenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cellsGlucose mediates the translocation of NeuroD1 by O-linked glycosylation.Quantitative dynamics of the link between cellular metabolism and histone acetylation.Reprogramming adult human dermal fibroblasts to islet-like cells by epigenetic modification coupled to transcription factor modulation.A novel histone deacetylase inhibitor prevents IL-1beta induced metabolic dysfunction in pancreatic beta-cells.The human insulin gene is part of a large open chromatin domain specific for human islets.Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells.Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion.Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.Chromatin modifications associated with diabetes.Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetesSOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.The role of butyrate, a histone deacetylase inhibitor in diabetes mellitus: experimental evidence for therapeutic intervention.Phenylbutyrate and β-cell function: contribution of histone deacetylases and ER stress inhibition.Regulation of insulin gene transcription by multiple histone acetyltransferases.COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1.Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages.The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose.Valproic Acid Improves Glucose Homeostasis by Increasing Beta-Cell Proliferation, Function, and Reducing its Apoptosis through HDAC Inhibition in Juvenile Diabetic Rat.Effects of the New Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m on High Glucose Induced Prolongation of Cardiac QT Interval and Increase of Coronary Perfusion Pressure.
P2860
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P2860
Glucose regulates insulin gene transcription by hyperacetylation of histone h4.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Glucose regulates insulin gene transcription by hyperacetylation of histone h4.
@en
type
label
Glucose regulates insulin gene transcription by hyperacetylation of histone h4.
@en
prefLabel
Glucose regulates insulin gene transcription by hyperacetylation of histone h4.
@en
P2860
P356
P1476
Glucose regulates insulin gene transcription by hyperacetylation of histone h4.
@en
P2093
Sabire Ozcan
P2860
P304
19660-19666
P356
10.1074/JBC.M212375200
P407
P577
2003-03-28T00:00:00Z