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Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligaseThe HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativityCDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformationHuman papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityRegulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitinationBrd4-independent transcriptional repression function of the papillomavirus e2 proteinsKaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomesStructure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascadeStructural studies of the interaction between ubiquitin family proteins and proteasome subunit S5aDNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5aInteraction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomesp300/MDM2 complexes participate in MDM2-mediated p53 degradationBovine papillomavirus E7 transformation function correlates with cellular p600 protein bindingVirus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivoNSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expressionRepression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells.NCoR1 mediates papillomavirus E8;E2C transcriptional repressionIdentification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomesGenus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes.Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses.Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells.Requirement of E7 oncoprotein for viability of HeLa cells.Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3BProteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cellsMouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequencesUbiquitin family proteins and their relationship to the proteasome: a structural perspective.Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.Differentiation of human epidermal cells transformed by SV40.Transformation and replication in mouse cells of a bovine papillomavirus--pML2 plasmid vector that can be rescued in bacteria.Interferon induces morphologic reversion with elimination of extrachromosomal viral genomes in bovine papillomavirus-transformed mouse cellsProteomic approaches to the study of papillomavirus-host interactions.Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Peter M Howley
@ast
Peter M Howley
@en
Peter M Howley
@es
Peter M Howley
@nl
type
label
Peter M Howley
@ast
Peter M Howley
@en
Peter M Howley
@es
Peter M Howley
@nl
prefLabel
Peter M Howley
@ast
Peter M Howley
@en
Peter M Howley
@es
Peter M Howley
@nl
P106
P1153
35512566600
P31
P496
0000-0002-8668-9579