Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
about
Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligaseE6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core proteinLatent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinasesRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligaseRegulation of protein tyrosine kinase signaling by substrate degradation during brain developmentMembrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformationNegative regulation of Lck by Cbl ubiquitin ligaseE3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6The ubiquitin-proteasome pathway and proteasome inhibitorsThe SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function.Regulation of the Src family kinase Lck by Hsp90 and ubiquitinationThe Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.E6AP gene suppression and characterization with in vitro selected hammerhead ribozymes.Human papillomaviruses: genetic basis of carcinogenicity.The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligaseRegulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndromeUbiquitin-mediated proteolysis: biological regulation via destruction.Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.Inhibition of SRC family kinases protects hippocampal neurons and improves cognitive function after traumatic brain injury.GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.Myristoylation and membrane binding regulate c-Src stability and kinase activityA mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo.Human papillomavirus infection and cyclin D1 gene amplification in laryngeal squamous cell carcinoma: biologic function and clinical significance.Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complexDistinct phenotypes distinguish the molecular classes of Angelman syndromeTumor viruses and cell signaling pathways: deubiquitination versus ubiquitinationAngelman Syndrome.TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.Molecular and Clinical Aspects of Angelman Syndrome.Understanding the pathogenesis of Angelman syndrome through animal modelsThe Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.Neurodevelopmental Underpinnings of Angelman Syndrome.Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1).COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer.Ubiquitin-mediated degradation of active Src tyrosine kinase
P2860
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P2860
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@ast
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@en
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@nl
type
label
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@ast
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@en
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@nl
prefLabel
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@ast
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@en
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@nl
P2860
P3181
P356
P1476
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
@en
P2860
P304
P3181
P356
10.1073/PNAS.96.17.9557
P407
P577
1999-08-01T00:00:00Z