about
Targeting innate immunity for neurodegenerative disorders of the central nervous systemThe role of microglia in adult hippocampal neurogenesisDevelopment of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic DysfunctionHippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the LiteratureSpirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferationDecreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain.Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanismUsing mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse modelsCX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models.Generation and behavior characterization of CaMKIIβ knockout mice.Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls.Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging.MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injuryThe p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's diseaseDevelopmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling ratsDiffuse brain injury induces acute post-traumatic sleep.Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brainRetention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi.Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.Increased neuronal proliferation in the dentate gyrus of aged rats following neural stem cell implantation.Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFαInhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.Cardiac arrest with cardiopulmonary resuscitation reduces dendritic spine density in CA1 pyramidal cells and selectively alters acquisition of spatial memory.Blockade of caspase-1 increases neurogenesis in the aged hippocampus.Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury.Early inhibition of TNFalpha increases 6-hydroxydopamine-induced striatal degeneration.Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis.Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.
P50
Q26744219-9E1FC762-9E14-4E35-B4F6-335AD27D81BFQ27023194-F5DFF544-64E1-4714-9C5A-43D4AD42CAD7Q27679012-B5EA9B9C-5C5B-483C-84CC-F6178B28CFDFQ28083841-5599FC1A-AD0E-48F1-9B11-B1FF4EA028B0Q28752354-8A063B4B-8416-44BE-B61F-938C07E108ABQ30493575-9F81D410-0056-4397-A724-01AE5B2A804BQ33319902-5E2838AE-E6FC-4C4D-8781-68E59F718F49Q34006977-4C2A5A1E-52EF-404C-A682-AD03405B29E7Q34324047-03E211A8-8ABC-4EDA-9194-8CFEA662CD77Q34418781-82A9D8C1-4CE5-4AFF-9E1B-7BB4B7AB911BQ34576624-9A28CD1A-7917-43C7-8D65-68BEA4186C90Q34607153-C2E48652-37BB-4E47-9129-7BA5F9067E8AQ35225794-E13ED7F9-BFCD-4305-8DA5-337D787DD312Q35515670-538EA282-B242-4ADE-A5AD-5AAC0F1BDC47Q35752300-C357A114-D92A-47F7-8C74-D35946AA0B0EQ35809944-875FAC26-985C-4976-AD13-FCF3F05EE588Q35922026-576E5828-2FCB-45FC-ADE9-301339B2127DQ36020203-09A3E76C-3B82-4440-9190-2C5211D7F88CQ36887359-A97F9ADA-94BA-4C19-8CD7-2C5ED327D336Q36997908-32475B6E-619D-4E3A-8FD8-87461A99215FQ37142339-DA4B0779-912F-4EC7-A176-842D5A7F1B04Q37451807-F6DDEF3C-357F-498B-9B1F-0170138B52DFQ37532581-85458E3C-0354-4C67-9CF5-4B5D6D51CACBQ38708742-03638021-5734-46CC-856A-2F35FF8253D9Q38764818-29E4B1A2-A4A9-46E5-A147-39FA535738C5Q38910326-581AA2B0-D808-4E7D-84A8-6B765C74C74FQ38915426-2CEF00B7-EE90-4D7C-8E5E-9E87A2FB842CQ39630216-0FF11CF8-F465-4AB1-AC49-67ABCBEAB2CAQ39830632-311AA803-8AE2-49FE-9E35-4F36B4816606Q42352469-6D7A87EC-8BBF-44A0-AB71-A1C9708DFC80Q42409231-702553D2-CFDD-436E-99A2-1F62222B2A8DQ42608624-95034C8C-CFF1-4D8B-86E8-CD04520CACD4Q43116264-5C5C5CDD-C4EA-4AE1-A83E-72F2352D8319Q45067731-7742D75C-F96C-47A5-9DA7-3D1F170D47BBQ46900878-32AB7718-EA0A-491F-911B-CC3A09C5B42CQ48056455-7F65B789-B698-48A7-98D6-53CBBA31C90CQ48250211-B8947569-BF1F-4B75-9575-C2BBE6E21BD1Q48512648-A9AD0238-7BB9-43FF-872D-4D48098A7FEAQ48520519-85FAC415-BA0F-42D5-9857-24C984F3297CQ55231012-AB63B289-77BB-45C1-938C-7E2F659CDA25
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Adam D Bachstetter
@ast
Adam D Bachstetter
@en
Adam D Bachstetter
@es
Adam D Bachstetter
@nl
type
label
Adam D Bachstetter
@ast
Adam D Bachstetter
@en
Adam D Bachstetter
@es
Adam D Bachstetter
@nl
prefLabel
Adam D Bachstetter
@ast
Adam D Bachstetter
@en
Adam D Bachstetter
@es
Adam D Bachstetter
@nl
P106
P21
P31
P496
0000-0003-4646-6757