about
CB1 cannabinoid receptors and on-demand defense against excitotoxicitySerotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's diseaseSynthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles.Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches.Arylpiperazine derivatives acting at 5-HT(1A) receptors.Chemical probes for the recognition of cannabinoid receptors in native systems.Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors.Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity.Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.Ligand chain length drives activation of lipid G protein-coupled receptors.New inhibitors of angiogenesis with antitumor activity in vivo.Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.Development of Fluorescent Ligands for the Human 5-HT1A Receptor.A cannabinoid link between mitochondria and memory.New synthetic inhibitors of fatty acid synthase with anticancer activity.Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors.Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.Development of molecular probes for the human 5-HT(6) receptor.2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells.The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study.The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors.A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer.Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide.Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.
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description
hulumtuese
@sq
researcher
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wetenschapper
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հետազոտող
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name
María L López-Rodríguez
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María L López-Rodríguez
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María L López-Rodríguez
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María L López-Rodríguez
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type
label
María L López-Rodríguez
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María L López-Rodríguez
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María L López-Rodríguez
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María L López-Rodríguez
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prefLabel
María L López-Rodríguez
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María L López-Rodríguez
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María L López-Rodríguez
@es
María L López-Rodríguez
@nl
P106
P1153
7005167822
P21
P31
P496
0000-0001-8607-1085