about
Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channelEffects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome.Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesiaActions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currentsOld and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cellsReceptor-mediated suppression of potassium currents requires colocalization within lipid raftsSubtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK.The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist.Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line.Recent advances in the molecular understanding of voltage-gated Ca2+ channels.Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampusModulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease.Vanilloid and TRP channels: a family of lipid-gated cation channels.Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1Altered Synapse Stability in the Early Stages of TauopathyDisrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse.Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy.Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide.Na(v)1.5 sodium channels in a human microglial cell line.Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy.TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia.Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors.Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones.Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice.Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole.Characterization of the human HCN1 channel and its inhibition by capsazepine.Discovery of small molecule antagonists of TRPV1.Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering.mRNA distribution analysis of human TRPC family in CNS and peripheral tissues.Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons.TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Andrew Randall
@ast
Andrew Randall
@en
Andrew Randall
@es
Andrew Randall
@nl
type
label
Andrew Randall
@ast
Andrew Randall
@en
Andrew Randall
@es
Andrew Randall
@nl
prefLabel
Andrew Randall
@ast
Andrew Randall
@en
Andrew Randall
@es
Andrew Randall
@nl
P108
P106
P108
P1153
7102425663
P31
P496
0000-0001-8852-3671