U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
about
The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA bindingAutomated de novo prediction of native-like RNA tertiary structuresNew insights into the spliceosome by single molecule fluorescence microscopyStructure and thermodynamics of a conserved U2 snRNA domain from yeast and humanMinimum-energy path for a u6 RNA conformational change involving protonation, base-pair rearrangement and base flippingStructure and functional implications of a complex containing a segment of U6 RNA bound by a domain of Prp24Structure of the yeast U2/U6 snRNA complexA conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligationCore structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolutionThe DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Splicing of a rare class of introns by the U12-dependent spliceosomeStructure of a self-splicing group II intron catalytic effector domain 5: parallels with spliceosomal U6 RNAA ribozyme that triphosphorylates RNA 5'-hydroxyl groupsSpliceosome Structure and FunctionIdentification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.Computational identification of four spliceosomal snRNAs from the deep-branching eukaryote Giardia intestinalis.Invariant U2 snRNA nucleotides form a stem loop to recognize the intron early in splicing.Protein-free small nuclear RNAs catalyze a two-step splicing reaction.Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptaseEvolution of group II intronsRibonucleoprotein multimers and their functions.Evidence for a group II intron-like catalytic triplex in the spliceosomeSingle-molecule analysis of protein-free U2-U6 snRNAs.Fluorescence and solution NMR study of the active site of a 160-kDa group II intron ribozyme.Spliceosome assembly in the absence of stable U4/U6 RNA pairing.Structure and stability of RNA/RNA kissing complex: with application to HIV dimerization initiation signalU2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicingFolding of the hammerhead ribozyme: pyrrolo-cytosine fluorescence separates core folding from global folding and reveals a pH-dependent conformational change.A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.Recognizing the 35th anniversary of the proposal that snRNPs are involved in splicing.NMR methods for studying the structure and dynamics of RNA.Three essential and conserved regions of the group II intron are proximal to the 5'-splice site.RNA-PAIRS: RNA probabilistic assignment of imino resonance shifts.Measuring the dynamic surface accessibility of RNA with the small paramagnetic molecule TEMPOL.Free energy landscapes of RNA/RNA complexes: with applications to snRNA complexes in spliceosomes.Spliceosomal snRNAs in the unicellular eukaryote Trichomonas vaginalis are structurally conserved but lack a 5'-cap structure.The spliceosome: a ribozyme at heart?Conformational heterogeneity of the protein-free human spliceosomal U2-U6 snRNA complexSubstrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.
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U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
description
im November 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 14 November 2004
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 2004
@uk
name
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
@en
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
@nl
type
label
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
@en
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
@nl
prefLabel
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
@en
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
@nl
P2093
P2860
P356
P1476
U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction
@en
P2093
David A Brow
Dipali G Sashital
Samuel E Butcher
P2860
P2888
P304
P356
10.1038/NSMB863
P577
2004-11-14T00:00:00Z