about
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicingRNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient miceDeletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kineticsFructose-driven glycolysis supports anoxia resistance in the naked mole-rat.Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeresIntegrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and diseaseThe tight junction protein CAR regulates cardiac conduction and cell-cell communication.Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo.Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscleDeconstructing sarcomeric structure-function relations in titin-BioID knock-in mice
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Michael H Radke
@ast
Michael H Radke
@en
Michael H Radke
@es
Michael H Radke
@nl
type
label
Michael H Radke
@ast
Michael H Radke
@en
Michael H Radke
@es
Michael H Radke
@nl
prefLabel
Michael H Radke
@ast
Michael H Radke
@en
Michael H Radke
@es
Michael H Radke
@nl
P106
P1153
36453097200
P31
P496
0000-0003-0112-9917