about
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance ProfilingA crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replicationInsights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 proteinNMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 ProteaseCrystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNASmall Molecule Inhibitors That Selectively Block Dengue Virus MethyltransferaseConformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an InhibitorA Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation ActivitiesDiscovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug DesignA novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing2'-O methylation of internal adenosine by flavivirus NS5 methyltransferaseArylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.Strategies for development of Dengue virus inhibitors.Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication.Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target.Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk.Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir.West Nile virus drug discovery.Ten years of dengue drug discovery: progress and prospects.Flavivirus RNA methylation.Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development.The dengue virus NS5 protein as a target for drug discovery.A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus.Biochemical and genetic characterization of dengue virus methyltransferase.Detection and quantification of flavivirus NS5 methyl-transferase activities.A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.Yellow fever virus NS3 protease: peptide-inhibition studies.A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.Dengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target.Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.Inducible system in human hepatoma cell lines for hepatitis C virus production.Cell-free transcription/translation from PCR-amplified DNA for high-throughput NMR studies.Differential polarization of immune responses by co-administration of antigens with chemokines.
P50
Q26247399-7C928B8D-14F3-462D-8EC0-1EB639AD6A27Q27321114-B35A02F8-F6DC-46A2-ACDB-B1032C6E9DD9Q27487462-7019650D-1DCA-4E88-B678-5430B0F3D3C3Q27490417-899B61DB-1F93-46CD-A34F-AA3564C457DDQ27664644-9006FE18-521F-4481-937D-5952EAFBD925Q27666321-C10D9D2E-4646-478E-A478-C0D342887A17Q27676371-6A3F14C7-568B-4BD6-BA50-6BED185B06D9Q27679917-EA0016C1-279D-485D-9A83-CCC4F5F73822Q27704260-E59A7838-8429-41E3-95D3-3EADAD787070Q28262564-0EA0B8CF-0FDF-4E3F-A284-375B5D38539BQ28482139-F4A8B322-E0F5-4E68-8D4B-1969D2E9F6D6Q32020871-6B4D281C-FFCD-4958-8995-CEC853184090Q33216390-A6DA52EC-AE3E-4735-9BAD-8144783F870FQ33527085-443CC5EC-3D02-4B16-A3E6-C8B4055F14EFQ34091777-A8CB05BC-56FD-4496-AE0E-14200C8F74A1Q35274810-EC44CA7D-E07A-469F-839A-471BE875B180Q35610381-361DD785-071B-4FB8-B995-E3C5053B2106Q36086353-6FD2A286-E86B-4846-846F-871BC4A6E4B8Q36354903-C21D1CAD-B80C-4589-ADFB-74942A9811FDQ37233223-972FACC9-20B3-4C7E-9C1D-DBCBED8A696AQ37428604-D8DF6A03-BE0F-4A01-A9FC-7BD02E90E022Q37547347-5580F018-CECF-415A-8902-E354510FA5F3Q37666750-E9AFF183-69B3-4A83-B5EB-96F34EDF0E04Q38146430-D04BBCD6-0562-4206-885C-6B5348D09D95Q38184248-94CC3B09-7803-46DC-A44D-CFAFA1865BC5Q38190336-6B9D479D-4D23-4726-B546-11B1ECC9CE4FQ38442511-64FDBF9D-49C8-4D0C-84A2-DEC1657ABBFAQ38912795-1AA09A29-6BCF-4C97-8E2B-EB66B504F80CQ38947082-043BEA94-5DF4-481E-870F-A76CC9550970Q38975991-8ABFF98D-C885-48B6-990F-2AA5CBFA9842Q39180065-E640ABFB-7C6A-4C38-A38A-D66B229DBA74Q39180077-C9E29B1F-2BB9-4599-8540-A0BE3D951783Q39197196-48555F5A-6C75-41BF-AFC3-9928589FEC91Q39307353-6EDCE9A8-8BC4-4685-BE46-D25B3C0C2DECQ39354663-3EE4AA14-5613-4938-BD81-D139900C95A9Q39616465-86646A1B-16A9-49B2-A56B-2DC1798F8739Q40484115-C271BC2C-B8E8-4E67-9080-9668E63932FBQ43041386-C047E75F-B507-4955-BB49-ADE7FEA70443Q51041023-D2FE8E83-1147-474E-8D32-EB688128DAB1Q51585260-DC0A8A30-B5FC-4140-AC19-03760A5C2DF5
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Siew Pheng Lim
@ast
Siew Pheng Lim
@en
Siew Pheng Lim
@es
Siew Pheng Lim
@nl
type
label
Siew Pheng Lim
@ast
Siew Pheng Lim
@en
Siew Pheng Lim
@es
Siew Pheng Lim
@nl
prefLabel
Siew Pheng Lim
@ast
Siew Pheng Lim
@en
Siew Pheng Lim
@es
Siew Pheng Lim
@nl
P106
P1153
9249798200
P31
P496
0000-0002-7377-5662