Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase - Test2 - elhamkhani - TriplyDB

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

http://www.wikidata.org/entity/Q27666321

about

Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme Predicting Zika virus structural biology: Challenges and opportunities for intervention Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities Structures of NS5 Methyltransferase from Zika Virus RNA methyltransferases involved in 5' cap biosynthesis Dengue: an update on treatment options The Zika virus methyltransferase: structure and functions for drug design perspectives Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase The crystal structure of Zika virus NS5 reveals conserved drug targets Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond Dengue Virus Non-Structural Protein 5 Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase OpenStructure: an integrated software framework for computational structural biology Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation.Inhibition of dengue virus by targeting viral NS4B protein Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus An enzyme-coupled high-throughput assay for screening RNA methyltransferase activity in E. coli cell lysate.S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase 5'-Silylated 3'-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus Identification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study.Screening Analogs of β-OG Pocket Binder as Fusion Inhibitor of Dengue Virus 2.Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity.Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever.Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication.Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)A novel inhibitor of dengue virus replication that targets the capsid protein Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs.A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein.West Nile virus drug discovery.Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.New developments in flavivirus drug discovery.An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection.Structural basis of Zika virus methyltransferase inhibition by sinefungin.Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors.

P2860

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P2860

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

http://www.wikidata.org/entity/Q27666321

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@ast

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@en

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@nl

type

label

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@ast

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@en

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@nl

prefLabel

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@ast

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@en

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@nl

P1433

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P2860

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P3181

P356

JBC.M110.179184

P1433

Journal of Biological Chemistry

P1476

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

@en

P2093

Alexander Theodore Chao

http://www.w3.org/2001/XMLSchema#string

Boping Liu

http://www.w3.org/2001/XMLSchema#string

Christian Noble

http://www.w3.org/2001/XMLSchema#string

Christophe Bodenreider

http://www.w3.org/2001/XMLSchema#string

Gang Wang

http://www.w3.org/2001/XMLSchema#string

Gladys Lee

http://www.w3.org/2001/XMLSchema#string

Hongping Dong

http://www.w3.org/2001/XMLSchema#string

Ka Yan Chung

http://www.w3.org/2001/XMLSchema#string

Louis Sebastian Sonntag

http://www.w3.org/2001/XMLSchema#string

Mei Ding

http://www.w3.org/2001/XMLSchema#string

P2860

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

Structure and Function of Flavivirus NS5 Methyltransferase

Analysis of Flavivirus NS5 Methyltransferase Cap Binding

Structure and mechanism of mRNA cap (guanine-N7) methyltransferase

The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends

Coot: model-building tools for molecular graphics

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

P304

6233-40

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scholarly article

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3635268

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P356

10.1074/JBC.M110.179184

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P407

P433

8

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P478

286

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P50

Thomas H. Keller

P577

2011-02-25T00:00:00Z

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21147775

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3057852

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