Nerve Growth Factor-induced p75-mediated Death of Cultured Hippocampal Neurons Is Age-dependent and Transduced through Ceramide Generated by Neutral Sphingomyelinase
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Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processesNeurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanismDCX, a new mediator of the JNK pathway.ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex.NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.Dual role for p75(NTR) signaling in survival and cell death: can intracellular mediators provide an explanation?Ceramide: second messenger or modulator of membrane structure and dynamics?3,4-methylenedioxyamphetamine upregulates p75 neurotrophin receptor protein expression in the rat brain.Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levelsA cell-biological model of p75NTR signaling.Ceramide signaling in cancer and stem cells.Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death.Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptorsDifferential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons.Cholinergic system during the progression of Alzheimer's disease: therapeutic implications.Bifidobacterium longum requires a fructokinase (Frk; ATP:D-fructose 6-phosphotransferase, EC 2.7.1.4) for fructose catabolismDrug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neuronsPolarization of hippocampal neurons with competitive surface stimuli: contact guidance cues are preferred over chemical ligands.Trk receptors need neutral sphingomyelinase activity to promote cell viability.Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons.Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase.Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of the mammalian p75 neurotrophin receptor.Nerve growth factor-induced glutamate release is via p75 receptor, ceramide, and Ca(2+) from ryanodine receptor in developing cerebellar neurons.Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75.A disaccharide derived from chondroitin sulphate proteoglycan promotes central nervous system repair in rats and mice.Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease.Subclinical hypothyroidism in pregnant rats impaired learning and memory in offspring by promoting p75NTR signaling.Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.
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Nerve Growth Factor-induced p75-mediated Death of Cultured Hippocampal Neurons Is Age-dependent and Transduced through Ceramide Generated by Neutral Sphingomyelinase
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Januar 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2002
@uk
name
Nerve Growth Factor-induced p7 ...... ed by Neutral Sphingomyelinase
@en
Nerve Growth Factor-induced p7 ...... ed by Neutral Sphingomyelinase
@nl
type
label
Nerve Growth Factor-induced p7 ...... ed by Neutral Sphingomyelinase
@en
Nerve Growth Factor-induced p7 ...... ed by Neutral Sphingomyelinase
@nl
prefLabel
Nerve Growth Factor-induced p7 ...... ed by Neutral Sphingomyelinase
@en
Nerve Growth Factor-induced p7 ...... ed by Neutral Sphingomyelinase
@nl
P2093
P2860
P356
P1476
Nerve Growth Factor-induced p7 ...... ed by Neutral Sphingomyelinase
@en
P2093
Adi B. Brann
Anthony H. Futerman
Ian M. Williams
Marianna Tcherpakov
P2860
P304
P356
10.1074/JBC.M109862200
P407
P577
2002-01-03T00:00:00Z