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Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparinStructure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activationThe crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamilyStructural Insights into Functional Overlapping and Differentiation among Myosin V MotorsRibosomal oxygenases are structurally conserved from prokaryotes to humansThe structural basis of ZMPSTE24-dependent laminopathiesCrystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processingAn overview of heavy-atom derivatization of protein crystalsStructural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide designStructural and mechanistic studies on γ-butyrobetaine hydroxylaseOn the need for an international effort to capture, share and use crystallization screening dataA multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron densityFunctional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome.Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).Gentle, fast and effective crystal soaking by acoustic dispensing.Squeezing the most from every crystal: the fine details of data collection.The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.Using textons to rank crystallization droplets by the likely presence of crystals.Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structuresOptimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitorLessons from ten years of crystallization experiments at the SGC.Application of in situ diffraction in high-throughput structure determination platforms.The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.Proper modelling of ligand binding requires an ensemble of bound and unbound states.Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites.WONKA: objective novel complex analysis for ensembles of protein-ligand structures.Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screensThe SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine binding protein.Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.Where is crystallography going?CCP4i2: the new graphical user interface to the CCP4 program suite.Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligasesA poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tetheringAchieving a Good Crystal System for Crystallographic X-Ray Fragment Screening
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description
researcher ORCID ID = 0000-0003-0378-0017
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wetenschapper
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name
Frank von Delft
@ast
Frank von Delft
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Frank von Delft
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Frank von Delft
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Frank von Delft
@ast
Frank von Delft
@en
Frank von Delft
@es
Frank von Delft
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prefLabel
Frank von Delft
@ast
Frank von Delft
@en
Frank von Delft
@es
Frank von Delft
@nl
P106
P21
P31
P496
0000-0003-0378-0017