Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
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A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chainsCrystal structure of the termination module of a nonribosomal peptide synthetaseDynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetaseStructural basis for the selectivity of the external thioesterase of the surfactin synthetaseCrystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domainsStructural modification of acyl carrier protein by butyryl groupStructural Characterization of OxyD, a Cytochrome P450 Involved in -Hydroxytyrosine Formation in Vancomycin BiosynthesisNMR-derived Topology of a GFP-photoprotein Energy Transfer ComplexSolution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide SynthaseStructural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide SynthetasesStructural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein DomainsStructure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein DomainsCrystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases.Structure of a Dinuclear Iron Cluster-Containing β-Hydroxylase Active in Antibiotic BiosynthesisStructure of the epimerization domain of tyrocidine synthetase AThe crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteinsStructure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesisHigh-resolution structures of the D-alanyl carrier protein (Dcp) DltC from Bacillus subtilis reveal equivalent conformations of apo- and holo-formsNew Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide SynthesisMycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatinSticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthaseThe role of dynamic conformational ensembles in biomolecular recognitionActivity-guided engineering of natural product carrier proteins.Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases.Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein.Nonribosomal peptide synthetases involved in the production of medically relevant natural products.A nuclear magnetic resonance method for probing molecular influences of substrate loading in nonribosomal peptide synthetase carrier proteinsPortability of the thiolation domain in recombinant pyoverdine non-ribosomal peptide synthetases.Assignment of methyl NMR resonances of a 52 kDa protein with residue-specific 4D correlation maps.Directed evolution of aryl carrier proteins in the enterobactin synthetase.Rigidifying acyl carrier protein domain in iterative type I PKS CalE8 does not affect its functionNonribosomal Peptide Synthesis-Principles and Prospects.Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined ContactsHarnessing natural product assembly lines: structure, promiscuity, and engineering.Structural Biology of Nonribosomal Peptide SynthetasesExplorations of catalytic domains in non-ribosomal peptide synthetase enzymologyGatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.The structural diversity of acidic lipopeptide antibiotics.Revisiting the modularity of modular polyketide synthases.
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Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
description
article publié dans la revue scientifique Science
@fr
im April 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Science
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 2006
@uk
name
Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
@en
Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
@nl
type
label
Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
@en
Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
@nl
prefLabel
Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
@en
Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
@nl
P2093
P50
P356
P1433
P1476
Conformational switches modulate protein interactions in peptide antibiotic synthetases
@en
P2093
Alexander Koglin
Birgit Schäfer
Frank Löhr
Marc-Michael Blum
Mohamed A Marahiel
Tanja Mittag
P304
P356
10.1126/SCIENCE.1122928
P407
P577
2006-04-01T00:00:00Z