Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation

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Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation

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scientific article published on 21 October 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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Gankyrin Drives Malignant Tran ...... e Stress via mTORC1 Activation

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Gankyrin Drives Malignant Tran ...... e Stress via mTORC1 Activation

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Gankyrin Drives Malignant Tran ...... e Stress via mTORC1 Activation

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Gankyrin Drives Malignant Tran ...... e Stress via mTORC1 Activation

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Gankyrin Drives Malignant Tran ...... e Stress via mTORC1 Activation

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Gankyrin Drives Malignant Tran ...... e Stress via mTORC1 Activation

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P1476

Gankyrin Drives Malignant Tran ...... e Stress via mTORC1 Activation

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Bo Huang

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Feng Liu

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Qian Wang

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Weiyang Cai

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Yanjie Zhang

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P2860

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Redox biology and gastric carcinogenesis: the role of Helicobacter pylori

Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb

Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

Role of bacteria in oncogenesis

The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53

Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6

The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation.

Oxidative stress and cancer: have we moved forward?

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9480316

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scholarly article

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10.1155/2018/9480316

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English

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2018

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P577

2018-10-21T00:00:00Z

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30420909

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Ageing

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6215549

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