Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb
about
A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cellsMAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activityThe ankyrin repeat as molecular architecture for protein recognitionThe other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axisThe crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6Cancer/testis antigens, gametogenesis and cancerEvidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.Gradually elevated expression of Gankyrin during human hepatocarcinogenesis and its clinicopathological significanceCoordinated expression of cyclin-dependent kinase-4 and its regulators in human oral tumors.Characterization of the binding interaction between the oncoprotein gankyrin and a grafted S6 ATPase.Regulation of CDK4Intracellular signaling and hepatocellular carcinoma.Biological functions of melanoma-associated antigensPrognostic and clinicopathological significance of Gankyrin overexpression in cancers: evidence from a meta-analysisUp-regulated oncoprotein P28GANK correlates with proliferation and poor prognosis of human glioma.Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53.Functional characterization of human oncoprotein gankyrin in Zebrafish.Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.Gankyrin regulates cell signaling network.Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.Overexpression of a new gene P28GANK confers multidrug resistance of gastric cancer cells.Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance.Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins.The study of pH-dependent stability shows that the TPLH-mediated hydrogen-bonding network is important for the conformation and stability of human gankyrin.Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice.Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.Resurfaced shape complementary proteins that selectively bind the oncoprotein gankyrin.Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in NASH/HCC axis.Unexpected Lower Expression of Oncoprotein Gankyrin in Drug Resistant ABCG2 Overexpressing Breast Cancer Cell LinesGankyrin: a novel promising therapeutic target for hepatocellular carcinoma.Cancer/testis antigen MAGE-A4 expression pattern differs in epithelial skin tumors of organ-transplant recipients and immunocompetent patients.Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation
P2860
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P2860
Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@ast
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@en
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@en-gb
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@nl
type
label
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@ast
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@en
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@en-gb
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@nl
prefLabel
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@ast
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@en
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@en-gb
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@nl
P921
P3181
P356
P1433
P1476
Novel insights into the INK4-C ...... mediated phosphorylation of Rb
@en
P2093
Ming-Daw Tsai
P304
P3181
P356
10.1021/BI011550S
P407
P577
2002-03-26T00:00:00Z