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GSK-3 Inhibitors: Preclinical and Clinical Focus on CNSGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.Glycogen synthase kinase 3: an emerging therapeutic target.Distinct molecular regulation of glycogen synthase kinase-3alpha isozyme controlled by its N-terminal region: functional role in calcium/calpain signaling.The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors.Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment.Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studiesPeptides targeting protein kinases: strategies and implications.Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.Peptide inhibitors targeting protein kinases.Substrate competitive GSK-3 inhibitors - strategy and implications.Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.Exploiting substrate recognition for selective inhibition of protein kinases.GSK-3 inhibition: achieving moderate efficacy with high selectivity.Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue.Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling.Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle.Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition.Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide.Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3.New insights into the autoinhibition mechanism of glycogen synthase kinase-3beta.Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner.The SIL gene is essential for mitotic entry and survival of cancer cells.Lithium-mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase-dependent activation of protein kinase C-alpha.Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc.Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice.GSK-3 and lysosomes meet in Alzheimer's disease.Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase.Elucidating substrate and inhibitor binding sites on the surface of GSK-3β and the refinement of a competitive inhibitor.Identification of novel glycogen synthase kinase-3beta substrate-interacting residues suggests a common mechanism for substrate recognition.Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.GSK-3β Inhibition Affects Singing Behavior and Neurogenesis in Adult Songbirds.
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description
researcher ORCID ID = 0000-0002-8460-9686
@en
wetenschapper
@nl
name
Hagit Eldar-Finkelman
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Hagit Eldar-Finkelman
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Hagit Eldar-Finkelman
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Hagit Eldar-Finkelman
@nl
type
label
Hagit Eldar-Finkelman
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Hagit Eldar-Finkelman
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Hagit Eldar-Finkelman
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Hagit Eldar-Finkelman
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prefLabel
Hagit Eldar-Finkelman
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Hagit Eldar-Finkelman
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Hagit Eldar-Finkelman
@es
Hagit Eldar-Finkelman
@nl
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0000-0002-8460-9686