Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies
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Lithium and autophagyLysosome and calcium dysregulation in Alzheimer's disease: partners in crimeLysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular ToxicityKnockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cellsChronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice.Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMPEnhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesisLongitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic micePreclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned?Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Low-level laser therapy ameliorates disease progression in a mouse model of Alzheimer's disease.Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.Acidic Ca2+ stores in neurodegeneration.Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.LRRK2: an éminence grise of Wnt-mediated neurogenesis?Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidificationRapamycin, Autophagy, and Alzheimer's DiseaseAmyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: implications for synaptic dysfunction and neuronal damageInhibition of glycogen synthase kinase 3β activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain.Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer's diseaseNeuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.Autophagic/lysosomal dysfunction in Alzheimer's disease.Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.GSK-3β, a pivotal kinase in Alzheimer disease.Protein recycling pathways in neurodegenerative diseases.Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations.Glycogen synthase kinase-3 as a therapeutic target for cognitive dysfunction in neuropsychiatric disorders.Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseasesActivation of mTOR: a culprit of Alzheimer's disease?Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells.High Glucose Enhances Isoflurane-Induced Neurotoxicity by Regulating TRPC-Dependent Calcium Influx.Multifunctional Effect of Human Serum Albumin Reduces Alzheimer's Disease Related Pathologies in the 3xTg Mouse Model.Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.Autophagy and Alzheimer's Disease.
P2860
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P2860
Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Inhibition of glycogen synthas ...... : in vivo and in vitro studies
@ast
Inhibition of glycogen synthas ...... : in vivo and in vitro studies
@en
type
label
Inhibition of glycogen synthas ...... : in vivo and in vitro studies
@ast
Inhibition of glycogen synthas ...... : in vivo and in vitro studies
@en
prefLabel
Inhibition of glycogen synthas ...... : in vivo and in vitro studies
@ast
Inhibition of glycogen synthas ...... : in vivo and in vitro studies
@en
P2093
P2860
P356
P1476
Inhibition of glycogen synthas ...... : in vivo and in vitro studies
@en
P2093
Dan Frenkel
Dorit Farfara
Limor Avrahami
Maya Shaham-Kol
Robert Vassar
P2860
P304
P356
10.1074/JBC.M112.409250
P407
P577
2012-11-15T00:00:00Z