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Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elementsThioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitorsDiazinones as P2 replacements for pyrazole-based cathepsin S inhibitorsA potent and selective histamine H4 receptor antagonist with anti-inflammatory propertiesIdentification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.Cathepsin S inhibitors as novel immunomodulators.TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders.Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.Identification of a potent and selective noncovalent cathepsin S inhibitor.The first potent and selective non-imidazole human histamine H4 receptor antagonists.Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979.Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S.The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells.Pyrazole-based cathepsin S inhibitors with improved cellular potencyAntigen Presenting Cells as Drug TargetsHistamine H4receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation
P50
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P50
name
Lars Karlsson
@ast
Lars Karlsson
@en
Lars Karlsson
@es
Lars Karlsson
@nl
type
label
Lars Karlsson
@ast
Lars Karlsson
@en
Lars Karlsson
@es
Lars Karlsson
@nl
prefLabel
Lars Karlsson
@ast
Lars Karlsson
@en
Lars Karlsson
@es
Lars Karlsson
@nl