about
Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathyInsulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylationInsulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesisRegulation of glucose homeostasis through a XBP-1-FoxO1 interactionDeletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta?Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthInsulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.Pdx1 restores beta cell function in Irs2 knockout mice.IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington diseaseIRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling.RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function.Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in miceSerine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.Direct autocrine action of insulin on β-cells: does it make physiological sense?The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistanceIrs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.Integrating metabolism and longevity through insulin and IGF1 signaling.Insulin signaling meets mitochondria in metabolism.Foxo1 integrates insulin signaling with mitochondrial function in the liver.cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis.Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function.Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling.c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade.Correction for Long et al., "Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways".kNOXing on the door of selective insulin resistance.The AKTion in non-canonical insulin signaling.Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.Irs1 serine 307 promotes insulin sensitivity in mice.Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance.Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes.Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue.Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation.Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis.Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.
P50
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P50
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Morris F White
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Morris F White
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Morris F White
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Morris F White
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Morris F White
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Morris F White
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Morris F White
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Morris F White
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Morris F White
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