about
Preclinical research in Rett syndrome: setting the foundation for translational success.DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution.Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.Cell type-specific DNA methylation at intragenic CpG islands in the immune system.Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.Reversibility of functional deficits in experimental models of Rett syndrome.The role of MeCP2 in the brain.Delivery of DNA into mammalian cells by receptor-mediated endocytosis and gene therapy.Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome.A mutation-led search for novel functional domains in MeCP2.Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2Toxicity of overexpressed MeCP2 is independent of HDAC3 activity
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description
researcher
@en
name
J Guy
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J Guy
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J Guy
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J Guy
@nl
prefLabel
J Guy
@en
J Guy
@nl
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0000-0002-8440-5667