Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. - Test2 - elhamkhani - TriplyDB

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.

http://www.wikidata.org/entity/Q36212795

about

Fingolimod for multiple sclerosis and emerging indications: appropriate patient selection, safety precautions, and special considerations The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.Recent advances in understanding synaptic abnormalities in Rett syndrome MECP2 disorders: from the clinic to mice and back BDNF deregulation in Rett syndrome Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?Fingolimod for the treatment of neurological diseases-state of play and future perspectives FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke Rett Syndrome: Reaching for Clinical Trials Advancing the understanding of autism disease mechanisms through genetics The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis Fingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy The role of microglia in brain maintenance: implications for Rett syndrome.A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome.Preclinical research in Rett syndrome: setting the foundation for translational success.Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination.Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis.Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells.An update on the biology of sphingosine 1-phosphate receptors.FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination.Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns Intervention in the context of development: pathways toward new treatments.Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis Fingolimod Treatment in Relapsing-Remitting Multiple Sclerosis Patients: A Prospective Observational Multicenter Postmarketing Study.Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy PTP1B inhibition suggests a therapeutic strategy for Rett syndrome PTP1B: a new therapeutic target for Rett syndrome Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic Stroke: A Pilot Trial.Fingolimod effects in neuroinflammation: Regulation of astroglial glutamate transporters?MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome.Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF.Synaptic regulation of affective behaviors; role of BDNF Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons

P2860

Q26765300-1277AFAB-590E-4A4E-A7FF-FCFCD6EC7C13 Q26766054-7475FB39-2649-4D8F-A25A-E85A35DB9EB4 Q26766164-62C76F51-40A9-4D88-92C1-448A026C13E9 Q26799760-3010ACAD-F348-4F5B-9E00-1E106836C42D Q27005901-19769914-9319-4DE3-B13E-F08D471E3BA3 Q27011473-116291CF-E8C5-4DC4-85F6-53F17D298335 Q27023257-C0E58AD7-2D9D-47AD-9A94-08DAA9596B13 Q27024207-B5D36750-9F3E-45A9-BC85-FB90BD8072F3 Q27026175-61C7DA0F-24CC-4A7F-B7EB-521971ABEBE4 Q27310503-C0F0ACF4-0870-4CA1-B55F-1DE7FCC385FF Q27337778-6CD75B7A-F16C-428F-9332-B31E0E2563F7 Q28069757-35F34B02-D089-4248-ACEF-D150E8660694 Q28073377-896B4D7F-C5D1-42BF-A85D-C934D2B52AE8 Q28486184-961E40C0-423C-47CC-8C8F-3F342DECAFCF Q28547298-DE1746B5-198F-4982-8B35-73CE7F31D53C Q28553993-9F3C94BB-39FB-4D46-9540-71340D5444CA Q30414657-D3BE305C-ECA2-4B88-8399-A6AC9883E1BC Q30431760-ADE599F6-1155-4884-B617-4FA4B0CD4B2E Q30527828-228B983C-A38C-4593-85C1-8DB87BBF0566 Q30605352-5479248C-16CB-4DFA-A9A9-436D930FEF58 Q30836800-4B8654EF-17DD-4B94-87DA-A57E300CE995 Q33735502-F93CF924-99E7-4742-B739-BDA921E8B9B2 Q33755345-D7434787-E503-4D4B-A84D-F80DBCD6D87C Q33889032-3748AC66-00DE-4D5D-84D4-C0DEDE8ED3DD Q33945064-53BE6F6E-F980-4A2A-BBBC-836C78853200 Q34105944-EA2334B8-2AAC-4B31-AF22-E17AB086FFB2 Q34614638-4FA5F5D8-C5F6-468A-882B-D4647E1BA5A8 Q34675928-4B7C6D12-A557-4038-B135-D1F7DEF099C2 Q35542637-31420217-0309-4F28-A4DF-600942EBA9D0 Q35920281-669050DB-9722-403D-A66A-21080C42AA1E Q35976992-7F0C9070-0A58-42F9-ADAD-D8842E502529 Q36040491-F905E311-C90D-497A-BCF3-AE29301E7FEA Q36040548-99212BA7-9F33-4C02-AD11-FFA4C0581FD4 Q36087056-363E07E5-E898-483A-8A43-B9856E063A39 Q36300679-E9CDEFDA-F24A-4955-8A7C-96CE439CDCD0 Q36549401-0E369FF2-C00D-463C-B9AB-B0A3BFABB42A Q36772101-F3A7D1FB-449E-460A-AE62-70AE6CDF8407 Q37277536-E59B1B56-7236-4E8F-AD49-A668BA7DC39D Q37302923-022DBF9A-09C7-4182-81A5-CD76615F1714 Q37413077-97E41040-6E73-42F1-8329-22F25A9CE37D

P2860

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.

http://www.wikidata.org/entity/Q36212795

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

Fingolimod, a sphingosine-1 ph ...... mouse model of Rett syndrome.

@ast

Fingolimod, a sphingosine-1 ph ...... mouse model of Rett syndrome.

@en

type

label

Fingolimod, a sphingosine-1 ph ...... mouse model of Rett syndrome.

@ast

Fingolimod, a sphingosine-1 ph ...... mouse model of Rett syndrome.

@en

prefLabel

Fingolimod, a sphingosine-1 ph ...... mouse model of Rett syndrome.

@ast

Fingolimod, a sphingosine-1 ph ...... mouse model of Rett syndrome.

@en

P1433

Q36212795-41AA4EA5-CAA3-48FE-9A44-304E03363627

P1476

Q36212795-DD443DBC-E5AC-4A9F-84ED-5632A9FCBBD2

P2093

Q36212795-062F3D5A-8830-4406-AFCC-9B15350E6F79

Q36212795-1BBB63AE-B59A-41D4-BB78-35CDE538BE4F

Q36212795-75E8F41E-27A6-4560-B85F-2FBF4FC42F1D

P2860

Q36212795-088B654D-2AB7-4DCA-81B1-588D15C0C003

Q36212795-0C1EE15C-DD6E-4B6F-94F2-835F0A7508F2

Q36212795-14C7099F-6BA8-4FE0-96B2-04B2D0938F45

Q36212795-1D4D70CB-1666-4DCA-95A9-846F1666A1A7

Q36212795-1F257C97-3178-4845-9EC8-BA0F115BACBA

Q36212795-2E524311-C6E2-4059-B70B-38C76A73C8B3

Q36212795-3AAC14AB-7598-42B8-95A8-239EA427BA9A

Q36212795-3FC31BCB-906A-4AC1-9EA9-AFD93A68239F

Q36212795-415B02AA-1C48-483C-8125-234E48E3279C

Q36212795-42EA0161-46DC-49C0-A7C9-139D040CD96C

P304

Q36212795-EE9EED7B-1353-4C4D-B0A5-615BEEBC8AA7

P31

Q36212795-9FC282BA-3B3B-4696-A085-C6DDCE5B70A7

P356

Q36212795-766EC4A8-6F9F-41F5-A6B3-F9A912AEFF30

P407

Q36212795-B73692BA-6238-4C12-81ED-15B3417A91CC

P433

Q36212795-70DF8074-108B-4969-A87C-AA42F01ADD75

P478

Q36212795-D195E2CC-EA10-4A09-A63F-7BA244DFE1E1

P50

Q36212795-2FB8F2CA-B114-493C-A8B1-3D6C6764863F

Q36212795-45BE9036-9CEC-4E12-8A2F-8EA743A5BD88

Q36212795-691471AF-E620-4B96-91E1-43A736FD7CB3

Q36212795-BEBD18B2-9715-44E8-B812-BBA13624E9A6

P577

Q36212795-8F0FF00F-2D06-40D6-81D0-6437D0EDED4B

P5875

Q36212795-FA9C18B2-1EF9-4279-9230-1ED910ADE4D5

P698

Q36212795-AEB69EDD-07C9-41D3-925E-92A095684875

P932

Q36212795-46FA67B7-946C-4D66-9E4C-D399910D38ED

P356

PNAS.1206093109

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Fingolimod, a sphingosine-1 ph ...... a mouse model of Rett syndrome

@en

P2093

Kaspar E Vogt

http://www.w3.org/2001/XMLSchema#string

Mihai Constantin S Ionescu

http://www.w3.org/2001/XMLSchema#string

Morteza Yazdani

http://www.w3.org/2001/XMLSchema#string

P2860

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain

Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

Function and regulation of CREB family transcription factors in the nervous system

Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice.

Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.

P304

14230-14235

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1206093109

http://www.w3.org/2001/XMLSchema#string

P407

P433

35

http://www.w3.org/2001/XMLSchema#string

P478

109

http://www.w3.org/2001/XMLSchema#string

P50

Yves-Alain Barde

Rubén Deogracias

Martijn P J Dekkers

P577

2012-08-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230666821

http://www.w3.org/2001/XMLSchema#string

P698

22891354

http://www.w3.org/2001/XMLSchema#string

P932

3435172

http://www.w3.org/2001/XMLSchema#string