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Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motifDistinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomicsSUMOylation-Mediated Regulation of Cell Cycle Progression and CancerMapping the SUMOylated landscapeA cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymescDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cellsIn vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategyA proteomic study of SUMO-2 target proteinsDifferential expression of tapasin and immunoproteasome subunits in adenovirus type 5- versus type 12-transformed cellsIdentification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.Uncovering global SUMOylation signaling networks in a site-specific mannerSUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.System-wide identification of wild-type SUMO-2 conjugation sites.PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.Label-Free Identification and Quantification of SUMO Target Proteins.A high-yield double-purification proteomics strategy for the identification of SUMO sites.Ubiquitin-dependent and independent roles of SUMO in proteostasis.c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joiningThe MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity.A comprehensive compilation of SUMO proteomics.RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).SUMO in the DNA damage response.The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.Converging Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Signaling: Improved Methodology Identifies Co-modified Target Proteins.Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis.Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress.SUMO targets the APC/C to regulate transition from metaphase to anaphase.Guiding Mitotic Progression by Crosstalk between Post-translational Modifications.Probing ubiquitin and SUMO conjugation and deconjugation.Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells.SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat ShockTotal Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific ProteasesWWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaksTranscription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation
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description
researcher
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wetenschapper
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A C Vertegaal
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A C Vertegaal
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A C Vertegaal
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A C Vertegaal
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prefLabel
A C Vertegaal
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A C Vertegaal
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P106
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0000-0002-7989-0493