Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.

Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.

Item
http://www.wikidata.org/entity/Q33315750
SUMOylation-Mediated Regulation of Cell Cycle Progression and CancerAutoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS DomainThe leukemia-associated fusion protein MN1-TEL blocks TEL-specific recognition sequences.ETV6 in hematopoiesis and leukemia predisposition.DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association.Mutation in SUMO E3 ligase, SIZ1, disrupts the mature female gametophyte in ArabidopsisDownregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitinationExtracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3.c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan.Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1).Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis.
P2860

Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.

Item
http://www.wikidata.org/entity/Q33315750
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
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2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Identification of a new site o ...... de of regulating Tel function.
@ast
Identification of a new site o ...... de of regulating Tel function.
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Identification of a new site of sumoylation on Tel
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type
label
Identification of a new site o ...... de of regulating Tel function.
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Identification of a new site o ...... de of regulating Tel function.
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Identification of a new site of sumoylation on Tel
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prefLabel
Identification of a new site o ...... de of regulating Tel function.
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Identification of a new site o ...... de of regulating Tel function.
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Identification of a new site of sumoylation on Tel
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P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
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P932
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P1433
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Identification of a new site o ...... ode of regulating Tel function
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P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932