about
Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiencyLysosomal processing of progranulinRegulation of cathepsin D activity by the FTLD protein progranulin.The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C.The lysosomal function of progranulin, a guardian against neurodegenerationSMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasisProgranulin deficiency leads to reduced glucocerebrosidase activity
P50
Q37609848-B27087D1-660D-4BFE-9DAE-D66F4B498057Q38611308-06F0076E-E8F2-40E0-BEAA-CCF5038F0272Q41495859-EC1C0B93-657A-448D-8695-A9AC133CCB3DQ48235284-D87DE8B4-86FC-4057-9EE0-701912DD2635Q56594618-92743A86-551A-4B97-A24D-1A7F1139267EQ64267462-E8E977D8-4A86-4226-A099-90016025627AQ91767691-522396C8-1006-4EA8-A9B9-06CD8E72B891
P50
description
researcher
@en
wetenschapper
@nl
name
Fenghua Hu
@en
Fenghua Hu
@nl
type
label
Fenghua Hu
@en
Fenghua Hu
@nl
prefLabel
Fenghua Hu
@en
Fenghua Hu
@nl
P31
P496
0000-0002-6447-9992