sameAs
Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligasePHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoformsThe phosphatase PHLPP controls the cellular levels of protein kinase CPHLiPPing the switch on Akt and protein kinase C signalingA genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase CTurning off AKT: PHLPP as a drug targetPHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growthProtein kinase C: poised to signalSuppression of survival signalling pathways by the phosphatase PHLPPProtein phosphatase PHLPP1 controls the light-induced resetting of the circadian clockCentrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesisAKAP-Lbc mobilizes a cardiac hypertrophy signaling pathwayThe mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase CCutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cellsProtein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation.Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007).Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation.Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes.Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitmentCalcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.Shedding light on local kinase activationProtein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases.Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesiaMislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigmCancer-associated protein kinase C mutations reveal kinase's role as tumor suppressorHydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1).Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.The ins and outs of protein kinase C.Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.A Ras activation pathway dependent on Syk phosphorylation of protein kinase CActive site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Alexandra C. Newton
@en
Alexandra C. Newton
@nl
Alexandra Newton
@de
Alexandra Newton
@es
Alexandra Newton
@fr
Alexandra Newton
@pt
type
label
Alexandra C. Newton
@en
Alexandra C. Newton
@nl
Alexandra Newton
@de
Alexandra Newton
@es
Alexandra Newton
@fr
Alexandra Newton
@pt
altLabel
A C Newton
@en
A Newton
@en
A. C. Newton
@en
A. Newton
@en
Alexandra C Newton
@en
Alexandra Newton
@en
Newton A
@en
Newton A. C.
@en
Newton A.
@en
Newton AC
@en
prefLabel
Alexandra C. Newton
@en
Alexandra C. Newton
@nl
Alexandra Newton
@de
Alexandra Newton
@es
Alexandra Newton
@fr
Alexandra Newton
@pt
P106
P19
P21
P31
P496
0000-0002-2906-3705