Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.
about
Turning off AKT: PHLPP as a drug targetSuppression of survival signalling pathways by the phosphatase PHLPPBiochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.From laptop to benchtop to bedside: structure-based drug design on protein targets.Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated AutophagyViewing serine/threonine protein phosphatases through the eyes of drug designersDual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respPleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes.MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue.Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heartIdentification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription.Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytesPHLPP phosphatases as a therapeutic target in insulin resistance-related diseases.PHLPPing through history: a decade in the life of PHLPP phosphatases.FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone.Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity.Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis.Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols.The cardiac re-AKT-ion to chronic volume overload.Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis.The Akt pathway in oncology therapy and beyond (Review)
P2860
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P2860
Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Discovery of small molecule in ...... hemical and virtual screening.
@ast
Discovery of small molecule in ...... hemical and virtual screening.
@en
type
label
Discovery of small molecule in ...... hemical and virtual screening.
@ast
Discovery of small molecule in ...... hemical and virtual screening.
@en
prefLabel
Discovery of small molecule in ...... hemical and virtual screening.
@ast
Discovery of small molecule in ...... hemical and virtual screening.
@en
P2860
P356
P1476
Discovery of small molecule in ...... hemical and virtual screening.
@en
P2093
Emma Sierecki
William Sinko
P2860
P304
P356
10.1021/JM100331D
P407
P577
2010-10-01T00:00:00Z