Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes
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Primary treatment of Crohn’s disease: combined antibiotics taking center stageIntracellular ion channels and cancerKv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseasesSynergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazoleThe antibody targeting the E314 peptide of human Kv1.3 pore region serves as a novel, potent and specific channel blockerActivity Profile of an FDA-Approved Compound Library against Schistosoma mansoniBlockade of Kv1.3 channels ameliorates radiation-induced brain injury.Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomasMolecular basis of calcium signaling in lymphocytes: STIM and ORAITargeting potassium channels Kv1.3 and KC a 3.1: routes to selective immunomodulators in autoimmune disorder treatment?Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel.Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.Clofazimine: current status and future prospects.Clofazimine analogs with efficacy against experimental tuberculosis and reduced potential for accumulation.The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression.Use of Kv1.3 blockers for inflammatory skin conditions.Chemical Analysis of Drug Biocrystals: A Role for Counterion Transport Pathways in Intracellular Drug Disposition.Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseasesSelective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis modelT Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 BlockersVoltage-gated potassium channels as therapeutic targets.Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.The functional network of ion channels in T lymphocytesImmunomodulatory effects of antimicrobial agents. Part I: antibacterial and antiviral agents.Mitochondrial ion channels as oncological targets.Mitochondrial channels: ion fluxes and more.The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies.Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline.Insight into the interaction of antitubercular and anticancer compound clofazimine with human serum albumin: spectroscopy and molecular modelling.Blockade of the Kv1.3 K+ Channel Enhances BCG Vaccine Efficacy by Expanding Central Memory T Lymphocytes.Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma.Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury.Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline.Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers: WO2010066840.Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cellsState-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine.Elucidating the interaction of clofazimine with bovine liver catalase; a comprehensive spectroscopic and molecular docking approach.The TRPM7 channel kinase regulates store-operated calcium entry.
P2860
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P2860
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@ast
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@en
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@en-gb
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@nl
type
label
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@ast
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@en
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@en-gb
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@nl
altLabel
Clofazimine Inhibits Human Kv1 ...... m Oscillation in T Lymphocytes
@en
prefLabel
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@ast
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@en
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@en-gb
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@nl
P2093
P2860
P50
P1433
P1476
Clofazimine inhibits human Kv1 ...... m oscillation in T lymphocytes
@en
P2093
Curtis R Chong
Hongsi Jiang
Suhel Parvez
Yunzhao R Ren
P2860
P356
10.1371/JOURNAL.PONE.0004009
P407
P577
2008-12-23T00:00:00Z