The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease
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Multiple Aspects of Gene Dysregulation in Huntington's DiseaseSubcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-ReviewIntermediate phenotypes and biomarkers of treatment outcome in major depressive disorderMind the gap: models in multiple species needed for therapeutic development in Huntington's diseaseTransgenic animal models for study of the pathogenesis of Huntington's disease and therapyHuntington's disease: underlying molecular mechanisms and emerging conceptsMutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytesAmitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis)Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivoCharacterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging studyTherapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse ModelKB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment.Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads databaseExtracts of adipose derived stem cells slows progression in the R6/2 model of Huntington's diseaseDegradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Neurodegenerative processes in Huntington's disease.Quality of Life of Cypriot Patients Suffering with Huntington's Disease.Oral treatment with the herbal formula B401 protects against aging-dependent neurodegeneration by attenuating oxidative stress and apoptosis in the brain of R6/2 miceTranslational research in Huntington's disease: opening up for disease modifying treatmentGlycation potentiates neurodegeneration in models of Huntington's disease.Quantitative Electroencephalographic Biomarkers in Preclinical and Human Studies of Huntington's Disease: Are They Fit-for-Purpose for Treatment Development?Collaboration versus outsourcing: the need to think outside the box.Advances in huntington disease drug discovery: novel approaches to model disease phenotypes.Aptamer and its applications in neurodegenerative diseases.The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's DiseaseMethylene Blue Partially Rescues Heart Defects in a Drosophila Model of Huntington's Disease.Model-Based Magnetization Transfer Imaging Markers to Characterize Patients and Asymptomatic Gene Carriers in Huntington's Disease.The challenge in translating basic research discoveries to treatment of Huntington disease.Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease.Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects.Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.Translation of MicroRNA-Based Huntingtin-Lowering Therapies from Preclinical Studies to the Clinic.REST overexpression in mice causes deficits in spontaneous locomotion
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The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease
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2011 nî lūn-bûn
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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The importance of integrating ...... erapies for Huntington disease
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The importance of integrating ...... erapies for Huntington disease
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The importance of integrating ...... erapies for Huntington disease
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The importance of integrating ...... erapies for Huntington disease
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type
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The importance of integrating ...... erapies for Huntington disease
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The importance of integrating ...... erapies for Huntington disease
@en
The importance of integrating ...... erapies for Huntington disease
@en-gb
The importance of integrating ...... erapies for Huntington disease
@nl
prefLabel
The importance of integrating ...... erapies for Huntington disease
@ast
The importance of integrating ...... erapies for Huntington disease
@en
The importance of integrating ...... erapies for Huntington disease
@en-gb
The importance of integrating ...... erapies for Huntington disease
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P2860
P3181
P356
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The importance of integrating ...... erapies for Huntington disease
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Gillian P. Bates
Ignacio Munoz-Sanjuan
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P3181
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10.1172/JCI45364
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P577
2011-02-01T00:00:00Z