The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
about
Plant and animal pathogen recognition receptors signal through non-RD kinasesA new role of NUAK1: directly phosphorylating p53 and regulating cell proliferationMO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADSIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase functionHeat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityHonokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesisSTK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreasGenetic risks and familial associations of small bowel carcinomaCrystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptorThe orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPKStem cell dynamics and pretumor progression in the intestinal tractLKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domainA role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndromeIonizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophyIdentification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndromeDevelopment and differentiation of the intestinal epitheliumThe LKB1-AMPK pathway: metabolism and growth control in tumour suppressionLKB1 modulates lung cancer differentiation and metastasisPopulation-based estimate of sibling risk for preterm birth, preterm premature rupture of membranes, placental abruption and pre-eclampsia.Mutations in STK11 gene in Czech Peutz-Jeghers patientsNo association between promoter polymorphism of STK11 gene and lung cancer risk in the Korean population.LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis.High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients.The coordinate regulation of the p53 and mTOR pathways in cells.The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance.Lower gastrointestinal tract cancer predisposition syndromesMolecular pathology of intraductal papillary mucinous neoplasms of the pancreas.Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposisInduction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiationTranslational advances regarding hereditary breast cancer syndromes.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.Alternative cell death mechanisms in development and beyond.Tumor Suppressor Serine/Threonine Kinase LKB1 Expression, Not Kinase Activity, Increased in the Vascular Smooth Muscle Cells and Neointima in the Rat Carotid Artery Injury ModelLKB1, a protein kinase regulating cell proliferation and polarity.LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome.
P2860
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P2860
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
description
2001 nî lūn-bûn
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2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@ast
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@en
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@en-gb
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@nl
type
label
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@ast
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@en
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@en-gb
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@nl
prefLabel
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@ast
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@en
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@en-gb
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@nl
P2093
P3181
P1433
P1476
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
@en
P2093
C D Bozzuto
L C Cantley
P304
P3181
P356
10.1016/S1097-2765(01)00258-1
P407
P577
2001-06-01T00:00:00Z