Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
about
Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinaseMicro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25STRAD pseudokinases regulate axogenesis and LKB1 stabilityIdentification of tumor-associated cassette exons in human cancer through EST-based computational prediction and experimental validationComplexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeRap2A links intestinal cell polarity to brush border formationMO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmMO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesCharacterization of three paralogous members of the Mammalian vaccinia related kinase familyComprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein networkLKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase functionCharacterization of an alternative splice variant of LKB1Signaling by target of rapamycin proteins in cell growth controlInteraction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations.Amino acids as regulators of gene expressionAMP-activated protein kinase, stress responses and cardiovascular diseasesHonokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesisThe tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressFyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1Host cell manipulation by the human pathogen Toxoplasma gondiiWNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cellsAt the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulationCordon bleu promotes the assembly of brush border microvilli.The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptorThe Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal AdhesionsNovel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondiiATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour SuppressorStructural insights into the activation of MST3 by MO25The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPKDiscovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3)STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cellsLKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domainA role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndromeFeeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in DrosophilaExpression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophyThe WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinasesProtein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons
P2860
Q21132307-FEBF911E-6516-45C6-AE59-A70C1A04400CQ21134128-94E35E4D-8238-4F1A-9663-001679A881A5Q21203071-8B92ECA8-0B69-44B2-AEE0-3C1190E1EEC0Q21245707-D480C95B-D67A-43FA-9E73-B6D85F624564Q21245891-ABE73E99-8C2F-419B-B8BE-26E07D448DEEQ24293320-874758DE-D01B-4E12-86F1-6880A9196472Q24296287-4A9C56C1-95F8-4C19-8F2D-6791A8F603C1Q24297671-428C0EFB-68E3-4B86-A714-0C33305641BBQ24300828-05CE91F4-4950-492B-A545-2E20C313DE51Q24301939-15F9392F-4EF3-4732-8E58-31C32F19948FQ24310603-7037BF07-0F03-4CB7-9BDF-188316BF878BQ24314737-D61EEC34-622E-410E-ACE5-B462BA77881DQ24319852-85BF356C-4B59-4940-96A4-638ECBCC510DQ24322647-5ABDCB72-E231-4A4E-9886-EF2F95D1B8A8Q24522447-FB058C2B-2B0E-4655-8478-C9AE35440421Q24535622-1EA2FF32-DE79-4522-BC4D-275E44813004Q24562847-62965B1E-C799-45CD-AF00-10FB7BB25187Q24610297-B43A95DC-FA70-4B38-B7D6-872E2A0DF64BQ24614006-16CF11D7-6543-49C2-A087-76295D27DBF6Q24633606-C41ED8FA-C55C-433A-B0CF-5B52DD211A8BQ24634669-CE99E43B-A92F-4E66-8AFE-FDB0D963BD75Q24650648-CFF26A63-6EB2-4DF9-A92A-6D43959F88F5Q24676697-88B5B4BA-5943-4AC5-B25E-4F4F3F562352Q24794909-5B8C35CF-8E21-41A5-8327-1F23F145217CQ27305309-B8500844-C26F-4F08-ACE2-E3F98C17C2ABQ27341809-4027FFE0-CA06-45F8-932A-320DCD83734CQ27642975-5ADA59D6-3AFD-4BE7-86C3-535C295870E7Q27646573-F7030FAB-DAC6-4ED3-97DA-0C1BE30FF614Q27653674-59E09529-5DC9-4EB1-85A5-E4DE1F883F54Q27655851-487C7523-17B1-4B59-BE3A-D4997889F414Q27675802-1D2AD72F-F789-40C8-B1B4-66C2DC7CD5FAQ27682265-4DF4C2AD-5F25-4F8B-B7D3-C3BEE9A60149Q27704783-8B595247-56F2-45C5-A069-60D890FCD359Q28264138-68A2F63C-8303-424B-8BB8-FD088FC58050Q28280001-4BDA4FC5-4655-4535-9CC7-5B7D1E298C0DQ28307804-655E5014-2A20-4739-8EE4-1B5CCDFDE7C4Q28547387-B5E35846-77AF-4D1A-90CE-6D864374210DQ28580464-4480F709-5A9A-4A3A-8CBB-52549F8C9500Q28583124-9AAAC68C-9A6E-4579-B04F-8F0A2E9F7F68Q28587247-E5DDA3ED-DB37-4541-A886-A899D2D2A657
P2860
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@ast
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@en
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@en-gb
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@nl
type
label
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@ast
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@en
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@en-gb
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@nl
prefLabel
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@ast
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@en
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@en-gb
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
@en
P2093
D R Alessi
G P Sapkota
H C Clevers
N A Morrice
P2860
P304
P3181
P356
10.1093/EMBOJ/CDG292
P407
P577
2003-06-16T00:00:00Z