An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
about
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesInhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interfaceRegulation of Ack1 localization and activity by the amino-terminal SAM domainMechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmentStructural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1Mechanism of activation and inhibition of the HER4/ErbB4 kinaseStructural basis for the recognition of c-Src by its inactivator CskConformational coupling across the plasma membrane in activation of the EGF receptorThe evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activityA secretory kinase complex regulates extracellular protein phosphorylationThe structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylationCharacterisation of HER heterodimers in breast cancer using in situ proximity ligation assayCell signaling by receptor tyrosine kinasesThe chemical biology of protein phosphorylationErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylationStructural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activationThe T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATPNeoadjuvant therapy for early-stage breast cancer: the clinical utility of pertuzumabCirculating DNA in diagnosis and monitoring EGFR gene mutations in advanced non-small cell lung cancerLigand-Independent EGFR SignalingAbscisic acid perception and signaling: structural mechanisms and applicationsRational approaches to improving selectivity in drug designCurrent role of EGF receptor monoclonal antibodies and tyrosine kinase inhibitors in the management of head and neck squamous cell carcinomaProfile of neratinib and its potential in the treatment of breast cancerThe epidermal growth factor receptor variant III (EGFRvIII): where wild things are alteredEGF receptor trafficking: consequences for signaling and cancerThe role of irreversible HER family inhibition in the treatment of patients with non-small cell lung cancerMolecular mechanisms of disease-causing missense mutationsDesign principles underpinning the regulatory diversity of protein kinasesEnhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancerOrchestration of ErbB3 signaling through heterointeractions and homointeractions.Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signalingInhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR SignalingCoarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylationThe Chlamydia pneumoniae invasin protein Pmp21 recruits the EGF receptor for host cell entrySingle Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated PitsStructure and regulation of the human Nek2 centrosomal kinaseStructures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor SensitivityThe Juxtamembrane Region of the EGF Receptor Functions as an Activation DomainStructural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
P2860
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P2860
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
An allosteric mechanism for ac ...... idermal growth factor receptor
@ast
An allosteric mechanism for ac ...... idermal growth factor receptor
@en
An allosteric mechanism for ac ...... idermal growth factor receptor
@en-gb
An allosteric mechanism for ac ...... idermal growth factor receptor
@nl
type
label
An allosteric mechanism for ac ...... idermal growth factor receptor
@ast
An allosteric mechanism for ac ...... idermal growth factor receptor
@en
An allosteric mechanism for ac ...... idermal growth factor receptor
@en-gb
An allosteric mechanism for ac ...... idermal growth factor receptor
@nl
prefLabel
An allosteric mechanism for ac ...... idermal growth factor receptor
@ast
An allosteric mechanism for ac ...... idermal growth factor receptor
@en
An allosteric mechanism for ac ...... idermal growth factor receptor
@en-gb
An allosteric mechanism for ac ...... idermal growth factor receptor
@nl
P2093
P3181
P1433
P1476
An allosteric mechanism for ac ...... idermal growth factor receptor
@en
P2093
Jodi Gureasko
Philip A Cole
Xuewu Zhang
P304
P3181
P356
10.1016/J.CELL.2006.05.013
P407
P50
P577
2006-06-16T00:00:00Z