The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
about
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interfaceChk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signallingGADD45gamma: a new vitamin D-regulated gene that is antiproliferative in prostate cancer cellsEmerging roles for intersectin (ITSN) in regulating signaling and disease pathwaysGene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cellsMitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant TransformationCancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling.Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptorMig6 haploinsufficiency protects mice against streptozotocin-induced diabetesMig-6 overcomes gefitinib resistance by inhibiting EGFR/ERK pathway in non-small cell lung cancer cell lines.The epidermal growth factor receptor family: biology driving targeted therapeutics.Mig-6 gene knockout induces neointimal hyperplasia in the vascular smooth muscle cell.Pathways driving the endocytosis of mutant and wild-type EGFR in cancer.miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy.The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6.PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cellsLoss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6The ErbB kinase domain: structural perspectives into kinase activation and inhibition.Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathwayInhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF.Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.Nuclear Gene 33/Mig6 Regulates the DNA Damage Response through an ATM-dependent Mechanism.Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.Intersectin scaffold proteins and their role in cell signaling and endocytosis.The mitogen-inducible gene-6 is involved in regulation of cellular senescence in normal diploid fibroblasts.Mutation of epidermal growth factor receptor is associated with MIG6 expression.A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor.A pervasive role for MIG6 in restraining cell proliferation.Feedback regulation of RTK signaling in development.Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6.
P2860
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P2860
The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The evolutionarily conserved E ...... of the EGFR catalytic activity
@ast
The evolutionarily conserved E ...... of the EGFR catalytic activity
@en
The evolutionarily conserved E ...... of the EGFR catalytic activity
@en-gb
The evolutionarily conserved E ...... of the EGFR catalytic activity
@nl
type
label
The evolutionarily conserved E ...... of the EGFR catalytic activity
@ast
The evolutionarily conserved E ...... of the EGFR catalytic activity
@en
The evolutionarily conserved E ...... of the EGFR catalytic activity
@en-gb
The evolutionarily conserved E ...... of the EGFR catalytic activity
@nl
prefLabel
The evolutionarily conserved E ...... of the EGFR catalytic activity
@ast
The evolutionarily conserved E ...... of the EGFR catalytic activity
@en
The evolutionarily conserved E ...... of the EGFR catalytic activity
@en-gb
The evolutionarily conserved E ...... of the EGFR catalytic activity
@nl
P2860
P50
P3181
P356
P1433
P1476
The evolutionarily conserved E ...... of the EGFR catalytic activity
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1210590
P407
P577
2007-06-18T00:00:00Z
P5875
P6179
1053166992