The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
about
Akt is negatively regulated by the MULAN E3 ligaseEmerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer developmentUbiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 responsePosttranslational regulation of Akt in human cancerLysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagyThe DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathwaysDeactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo.Commonality in Down and fetal alcohol syndromes.Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypesExtensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling.mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.Control of mTORC1 signaling by the Opitz syndrome protein MID1.A mechanism for asymmetric cell division resulting in proliferative asynchronicity.Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome systemThe ubiquitin-proteasome system meets angiogenesis.Non-canonical Activation of Akt in Serum-Stimulated Fibroblasts, Revealed by Comparative Modeling of Pathway DynamicsTransformation by E1A oncoprotein involves ubiquitin-mediated proteolysis of the neuronal and tumor repressor REST in the nucleus.K63-linked ubiquitination in kinase activation and cancer.Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis.Okadaic acid induces Akt hyperphosphorylation and an oxidative stress-mediated cell death in serum starved SK-N-SH human neuroblastoma cells that are augmented by rapamycin.Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancerDown syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.Achieving specificity in Akt signaling in cancer.Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer diseaseHeat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradationThe SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth.Akt/PKB: one kinase, many modifications.Phosphorylation-dependent Akt-Inversin interaction at the basal body of primary cilia.Akt2 and p-Akt overexpression in oral cancer cells is due to a reduced rate of protein degradation.Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.Mitochondrial E3 Ubiquitin Protein Ligase 1 Mediates Cigarette Smoke-Induced Endothelial Cell Death and Dysfunction.Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis.Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle.Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy.FOXO3 induces ubiquitylation of AKT through MUL1 regulation.
P2860
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P2860
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@ast
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@en
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@en-gb
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@nl
type
label
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@ast
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@en
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@en-gb
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@nl
prefLabel
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@ast
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@en
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@en-gb
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@nl
P2093
P921
P3181
P1433
P1476
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
@en
P2093
Akiko J Okumura
Chikashi Obuse
Fumihiko Okumura
Futoshi Suizu
Jun Yokota
Mami Matsuda
Masayuki Noguchi
Masumi Narita
Miyuki Bohgaki
Noriyuki Hirata
P304
P3181
P356
10.1016/J.DEVCEL.2009.09.007
P407
P577
2009-12-01T00:00:00Z