Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development
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The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesisRole of Ubiquitin-Mediated Degradation System in Plant BiologyNitric-oxide synthase trafficking inducer is a pleiotropic regulator of endothelial cell function and signaling.Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6)pVHL mediates K63-linked ubiquitination of nCLU.mRNA expression levels and genetic status of genes involved in the EGFR and NF-κB pathways in metastatic non-small-cell lung cancer patients.Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletionK63-linked ubiquitination in kinase activation and cancer.Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signalingThe Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesisOkadaic acid induces Akt hyperphosphorylation and an oxidative stress-mediated cell death in serum starved SK-N-SH human neuroblastoma cells that are augmented by rapamycin.Targeting ubiquitination for cancer therapies.The expression and clinical significance of HERC4 in breast cancer.Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling.K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progressionmiR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-κB and sustains NF-κB activation by decreasing Cylindromatosis expression.Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress.Deubiquitinases in the regulation of NF-κB signaling.Chemistry and biology of the ubiquitin signal.N6-Isopentenyladenosine promoted HeLa cell apoptosis through inhibitions of AKT and transforming growth factor β-activated kinase 1 activation.A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis.The Linear Ubiquitin Assembly Complex Modulates Latent Membrane Protein 1 Activation of NF-κB and Interferon Regulatory Factor 7.SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression.H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modificationsTransition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression.E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity.TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis.RNPS1 is modulated by ubiquitin-specific protease 4.A novel reporter for real-time, quantitative imaging of AKT-directed K63-poly-ubiquitination in living cells.Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System."Toll-free" pathways for production of type I interferons
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Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development
description
2010 nî lūn-bûn
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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@ast
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@en
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
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type
label
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@ast
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@en
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@nl
prefLabel
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@ast
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@en
Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@nl
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Emerging role of Lys-63 ubiqui ...... ivation and cancer development
@en
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10.1038/ONC.2010.190
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2010-08-12T00:00:00Z
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1035453093