Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells
about
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of SykPD-1 and its ligands are important immune checkpoints in cancerThe Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclustersDok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in miceNo receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memoryComplex phosphorylation dynamics control the composition of the Syk interactome in B cells.Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands.Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.Semi-supervised prediction of SH2-peptide interactions from imbalanced high-throughput data.Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling.Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformationLynA regulates an inflammation-sensitive signaling checkpoint in macrophages.Ca(2+) signaling in antigen receptor-activated B lymphocytes.A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages.Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca2+i signal in B cells.Docking proteins.Signaling mechanisms regulating B-lymphocyte activation and tolerance.Role of Calcium Signaling in B Cell Activation and Biology.The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.Spatiotemporal resolution of Ca2+ signaling events by real time imaging of single B cells.TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling.Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity.Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells.Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells.CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity
P2860
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P2860
Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@ast
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@en
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@en-gb
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@nl
type
label
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@ast
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@en
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@en-gb
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@nl
prefLabel
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@ast
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@en
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@en-gb
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@nl
P2093
P2860
P3181
P356
P1433
P1476
Subcellular localization of Gr ...... y of Ca2+ signaling in B cells
@en
P2093
Ingo Goldbeck
Jürgen Wienands
Konstantin Neumann
Michael Engelke
Michael Naumann
Thilo Kähne
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601557
P407
P577
2007-02-21T00:00:00Z