Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling
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p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transductionStructural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cellsLeupaxin negatively regulates B cell receptor signalingDok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCFInhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and functionNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationp135 src homology 2 domain-containing inositol 5'-phosphatase (SHIPbeta ) isoform can substitute for p145 SHIP in fcgamma RIIB1-mediated inhibitory signaling in B cellsDocking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory moleculesDok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganizationRegulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene productA spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnessesp62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)Association of Csk to VE-cadherin and inhibition of cell proliferationSHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKLThe Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclustersNck adapter proteins: functional versatility in T cellsPhosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion.Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in miceDomain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.mRNA expression of DOK1-6 in human breast cancerDownstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.Dok-4 is a novel negative regulator of T cell activation.Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and functionDOK4 and DOK5: new Dok-related genes expressed in human T cells.Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.DOK3 negatively regulates LPS responses and endotoxin tolerance.Adapters in the organization of mast cell signaling.Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.Adaptors as central mediators of signal transduction in immune cells.Transmembrane adapters: attractants for cytoplasmic effectors.Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformationNegative feedback of T cell activation through inhibitory adapters and costimulatory receptors.Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.
P2860
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P2860
Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling
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2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
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Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
@en
Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
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Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
@ast
Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
@en
Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
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Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
@ast
Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
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Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
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P2093
P2860
P1476
Dok-3, a novel adapter molecul ...... on of immunoreceptor signaling
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P2093
P2860
P304
P356
10.1128/MCB.20.8.2743-2754.2000
P407
P577
2000-04-01T00:00:00Z