Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression - Wikidata - thesis-toulmin - TriplyDB

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

http://www.wikidata.org/entity/Q24301470

about

DLC-1: a Rho GTPase-activating protein and tumour suppressor The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2 DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities Deleted in liver cancer-1 (DLC1): an emerging metastasis suppressor gene Solution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1 DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function Deleted in liver cancer protein family in human malignancies (Review)The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain Tensin1 positively regulates RhoA activity through its interaction with DLC1 Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion.Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase Y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphoma Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion.Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.CDK5 is a major regulator of the tumor suppressor DLC1 Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis.EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort.Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.

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P2860

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

http://www.wikidata.org/entity/Q24301470

description

2006 nî lūn-bûn

@nan

2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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Interaction of deleted in live ...... lications in tumor suppression

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0008-5472.CAN-05-2850

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Cancer Research

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Interaction of deleted in live ...... lications in tumor suppression

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Chung-Yiu Chan

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Dong-Yan Jin

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Frankie Chi Fat Ko

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4812000

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10.1158/0008-5472.CAN-05-2850

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17

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66

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Judy Wai Ping Yam

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2006-09-01T00:00:00Z

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16951145

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P921

negative regulation of Rho protein signal transduction

DLC1 Rho GTPase activating protein