Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity
about
Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brainFGF21 N- and C-termini play different roles in receptor interaction and activationNovel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerizationThe alternatively spliced acid box region plays a key role in FGF receptor autoinhibitionReceptor specificity of the fibroblast growth factor family. The complete mammalian FGF familyImpaired FGF signaling contributes to cleft lip and palateExploring mechanisms of FGF signalling through the lens of structural biologyHomodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular MatrixAntibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in micePlasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth FactorsNovel FGFR3 mutations creating cysteine residues in the extracellular domain of the receptor cause achondroplasia or severe forms of hypochondroplasiaGenetic variation at hair length candidate genes in elephants and the extinct woolly mammothMolecular mechanisms of fibroblast growth factor signaling in physiology and pathologyMultiple consequences of a single amino acid pathogenic RTK mutation: the A391E mutation in FGFR3NMR structure of the first Ig module of mouse FGFR1A spatial simulation approach to account for protein structure when identifying non-random somatic mutationsCompositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexesActivation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice.Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function.A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth.Microfluidic perfusion for regulating diffusible signaling in stem cells.Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.Physical basis behind achondroplasia, the most common form of human dwarfism.The Fibroblast Growth Factor signaling pathwayRole of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.Fibroblast growth factor receptors in breast cancer.Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A).Incidence, phenotypic features and molecular genetics of Kallmann syndrome in Finland.The evolutionary fate of alternatively spliced homologous exons after gene duplication.An essential role for FGF receptor signaling in lens developmentKlotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligandsp38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice.Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment.Nectin-1 binds and signals through the fibroblast growth factor receptorStructural systems biology: modelling protein interactions.Optimal drug cocktail design: methods for targeting molecular ensembles and insights from theoretical model systems.The structural biology of the FGF19 subfamilyTetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies.
P2860
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P2860
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Insights into the molecular ba ...... and ligand-binding promiscuity
@ast
Insights into the molecular ba ...... and ligand-binding promiscuity
@en
Insights into the molecular ba ...... and ligand-binding promiscuity
@en-gb
Insights into the molecular ba ...... and ligand-binding promiscuity
@nl
type
label
Insights into the molecular ba ...... and ligand-binding promiscuity
@ast
Insights into the molecular ba ...... and ligand-binding promiscuity
@en
Insights into the molecular ba ...... and ligand-binding promiscuity
@en-gb
Insights into the molecular ba ...... and ligand-binding promiscuity
@nl
prefLabel
Insights into the molecular ba ...... and ligand-binding promiscuity
@ast
Insights into the molecular ba ...... and ligand-binding promiscuity
@en
Insights into the molecular ba ...... and ligand-binding promiscuity
@en-gb
Insights into the molecular ba ...... and ligand-binding promiscuity
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Insights into the molecular ba ...... and ligand-binding promiscuity
@en
P2093
Angela Raucci
Anna V Eliseenkova
Avner Yayon
Claudio Basilico
Fuming Zhang
Omar A Ibrahimi
P2860
P304
P3181
P356
10.1073/PNAS.0307287101
P407
P577
2004-01-27T00:00:00Z