NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
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Mutational activation of the MAP3K8 protooncogene in lung cancerABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stabilityProstaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activationMaintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cellsLoss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesisUbiquitin signaling in immune responsesThe Regulation of NF-κB Subunits by PhosphorylationTumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerRegulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseMAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomasAltered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout miceThe protein kinase TPL2 is essential for ERK1/ERK2 activation and cytokine gene expression in airway epithelial cells exposed to pathogen-associated molecular patterns (PAMPs)ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responsesCrosstalk in NF-κB signaling pathwaysIκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinasesTPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth.Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50.TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling.The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes.TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activationFunctions of NF-kappaB1 and NF-kappaB2 in immune cell biologyp38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activationCoordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.TPL2 kinase is a suppressor of lung carcinogenesisCoordinating TLR-activated signaling pathways in cells of the immune system.Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide.Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cellsRETRACTED: GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation.Mitogen-activated protein kinase-mediated licensing of interferon regulatory factor 3/7 reinforces the cell response to virusLipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.IκB kinase regulation of the TPL-2/ERK MAPK pathway.Protein kinase networks that limit TLR signalling.A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.
P2860
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P2860
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@ast
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@en
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@en-gb
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@nl
type
label
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@ast
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@en
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@en-gb
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@nl
prefLabel
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@ast
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@en
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@en-gb
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@nl
P2093
P2860
P921
P3181
P1476
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
@en
P2093
M P Belich
P A Walker
S J Gamblin
P2860
P304
P3181
P356
10.1128/MCB.23.14.4739-4752.2003
P407
P577
2003-07-01T00:00:00Z