Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
about
Mutational activation of the MAP3K8 protooncogene in lung cancerABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stabilityNF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activityA human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathwaysHPK1, a hematopoietic protein kinase activating the SAPK/JNK pathwayActivation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinaseInteraction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsMEK kinases are regulated by EGF and selectively interact with Rac/Cdc42The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformationLoss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesisThe COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activityTpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondiiThe oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerTpl2 knockout keratinocytes have increased biomarkers for invasion and metastasisRegulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseMAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomasAltered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout miceHow MAP kinase modules function as robust, yet adaptable, circuitsGenetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factorsTpl2/AP-1 enhances murine gammaherpesvirus 68 lytic replication.Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity.IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinasesPhosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage.Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cellsTLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-thetaMitogen and stress activated kinases act co-operatively with CREB during the induction of human cytomegalovirus immediate-early gene expression from latency.Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis.Functions of NF-kappaB1 and NF-kappaB2 in immune cell biologyFoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury.
P2860
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P2860
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
description
1996 nî lūn-bûn
@nan
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@ast
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@en
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@nl
type
label
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@ast
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@en
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@nl
prefLabel
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@ast
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@en
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@nl
P2093
P2860
P3181
P1433
P1476
Activation of MEK-1 and SEK-1 ...... novel MAP kinase kinase kinase
@en
P2093
P2860
P304
P3181
P407
P577
1996-02-15T00:00:00Z