The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling
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Hedgehog Signaling in the Maintenance of Cancer Stem CellsHedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteAll Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved MannerStructural insights into proteoglycan-shaped Hedgehog signalingHedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinomaSmoothened goes molecular: new pieces in the hedgehog signaling puzzleClassification of genes and putative biomarker identification using distribution metrics on expression profilesBioinformatic description of immunotherapy targets for pediatric T-cell leukemia and the impact of normal gene sets used for comparison.Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Differential involvement of Hedgehog signaling in butterfly wing and eyespot development.Molecular dynamics simulations of sonic hedgehog-receptor and inhibitor complexes and their applications for potential anticancer agent discoveryDesign and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form.Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidaseA Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndromeSecreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function46,XY Gonadal Dysgenesis due to a Homozygous Mutation in Desert Hedgehog (DHH) Identified by Exome SequencingHedgehog secretion and signal transduction in vertebrates.Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cellsParasite prolyl oligopeptidases and the challenge of designing chemotherapeuticals for Chagas disease, leishmaniasis and African trypanosomiasisTargeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment.Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets.Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer.Structural and mechanistic insight into how antibodies inhibit serine proteases.Interactions between Hedgehog proteins and their binding partners come into view.Nonclassical hedgehog-GLI signaling and its clinical implications.Pseudoproteases: mechanisms and function.Development of anticancer agents targeting the Hedgehog signaling.An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactionsThe influence of metal-ion binding on the structure and surface composition of Sonic Hedgehog: a combined classical and hybrid QM/MM MD study.Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations.Biophysical characterisation of the novel zinc binding property in Suppressor of Fused.Structural architecture and functional evolution of WntsCysteine-rich domains related to Frizzled receptors and Hedgehog-interacting proteins.Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferationStromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms.Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs.Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling.The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study.Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.
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The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The structure of SHH in comple ...... seudo active site in signaling
@ast
The structure of SHH in comple ...... seudo active site in signaling
@en
The structure of SHH in comple ...... seudo active site in signaling
@en-gb
The structure of SHH in comple ...... seudo active site in signaling
@nl
type
label
The structure of SHH in comple ...... seudo active site in signaling
@ast
The structure of SHH in comple ...... seudo active site in signaling
@en
The structure of SHH in comple ...... seudo active site in signaling
@en-gb
The structure of SHH in comple ...... seudo active site in signaling
@nl
prefLabel
The structure of SHH in comple ...... seudo active site in signaling
@ast
The structure of SHH in comple ...... seudo active site in signaling
@en
The structure of SHH in comple ...... seudo active site in signaling
@en-gb
The structure of SHH in comple ...... seudo active site in signaling
@nl
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The structure of SHH in comple ...... seudo active site in signaling
@en
P2093
Andreas Lingel
Frederic J de Sauvage
Henry R Maun
Ivan Bosanac
J Fernando Bazan
Robert A Lazarus
Sarah G Hymowitz
Xiaohui Wen
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P2888
P304
P3181
P356
10.1038/NSMB.1632
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P577
2009-06-28T00:00:00Z
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1041793708