Geminin, an inhibitor of DNA replication, is degraded during mitosis
about
The function of APC/CCdh1 in cell cycle and beyondIdentification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complexA novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cellsTreslin collaborates with TopBP1 in triggering the initiation of DNA replicationCdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinFez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cellsIdas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionThe regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cellsA WD-repeat protein stabilizes ORC binding to chromatinTwo E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrateDTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpointCdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin bindingMutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesisChromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosisFunctional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.Geminin regulates neuronal differentiation by antagonizing Brg1 activityTiming of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes.Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidizationThe chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Regulation of replication licensing by acetyltransferase Hbo1.Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycleNonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosisLoss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damageHuman geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosisRereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpointCell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated stateReplication licensing and cancer--a fatal entanglement?Preventing re-replication of chromosomal DNA.Endoreplication: polyploidy with purposeThe anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cyclesLoss of Geminin induces rereplication in the presence of functional p53Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progressionThe Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit
P2860
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P2860
Geminin, an inhibitor of DNA replication, is degraded during mitosis
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@ast
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@en
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@en-gb
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@nl
type
label
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@ast
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@en
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@en-gb
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@nl
prefLabel
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@ast
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@en
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@en-gb
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@nl
P3181
P1433
P1476
Geminin, an inhibitor of DNA replication, is degraded during mitosis
@en
P2093
M W Kirschner
T J McGarry
P304
P3181
P356
10.1016/S0092-8674(00)81209-X
P407
P577
1998-06-12T00:00:00Z