An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules
about
Ubiquitination of human leukocyte antigen (HLA)-DM by different membrane-associated RING-CH (MARCH) protein family E3 ligases targets different endocytic pathwaysHLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transportMapping the HLA-DO/HLA-DM complex by FRET and mutagenesisSmall molecules that enhance the catalytic efficiency of HLA-DMThe role of major histocompatibility complex molecules in luteal functionHuman leukocyte Antigen-DM polymorphisms in autoimmune diseasesA step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsMHC Class II Auto-Antigen Presentation is UnconventionalAn MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient miceAntigen processing and presentation by a murine myoblast cell lineHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismCrystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionConformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchangeDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IISusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionAltered major histocompatibility complex class II peptide loading in H2-O-deficient miceH2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 miceEditing of the HLA-DR-peptide repertoire by HLA-DMDecreased endosomal delivery of major histocompatibility complex class II-invariant chain complexes in dynamin-deficient cellsThe impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II moleculesIi-Key/MHC class II epitope hybrids: a strategy that enhances MHC class II epitope loading to create more potent peptide vaccines.Enhanced expression of CD74 in gastrointestinal cancers and benign tissuesThe contributions of mass spectrometry to understanding of immune recognition by T lymphocytes.Definition of agonists and design of antagonists for alloreactive T cell clones using synthetic peptide libraries.Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates.Probe selection and expression index computation of Affymetrix Exon Arrays.HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideTruncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes.Sequence organisation of the class II region of the human MHC.Pathways of antigen processing.HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis.Mechanisms of antigen presentation.Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors.Peptide exchange in MHC molecules.Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange.The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation.Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41.Stoichiometry of HLA class II-invariant chain oligomersCorrelation in chicken between the marker LEI0258 alleles and Major Histocompatibility Complex sequences.
P2860
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P2860
An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules
description
1994 nî lūn-bûn
@nan
1994 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
An essential role for HLA-DM i ...... r histocompatibility molecules
@ast
An essential role for HLA-DM i ...... r histocompatibility molecules
@en
An essential role for HLA-DM i ...... r histocompatibility molecules
@en-gb
An essential role for HLA-DM i ...... r histocompatibility molecules
@nl
type
label
An essential role for HLA-DM i ...... r histocompatibility molecules
@ast
An essential role for HLA-DM i ...... r histocompatibility molecules
@en
An essential role for HLA-DM i ...... r histocompatibility molecules
@en-gb
An essential role for HLA-DM i ...... r histocompatibility molecules
@nl
prefLabel
An essential role for HLA-DM i ...... r histocompatibility molecules
@ast
An essential role for HLA-DM i ...... r histocompatibility molecules
@en
An essential role for HLA-DM i ...... r histocompatibility molecules
@en-gb
An essential role for HLA-DM i ...... r histocompatibility molecules
@nl
P2093
P3181
P356
P1433
P1476
An essential role for HLA-DM i ...... r histocompatibility molecules
@en
P2093
J J Monaco
P2888
P3181
P356
10.1038/368551A0
P407
P577
1994-04-07T00:00:00Z
P6179
1041174437