Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection - Wikidata - thesis-toulmin - TriplyDB

Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection

Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection

http://www.wikidata.org/entity/Q27675568

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Human leukocyte Antigen-DM polymorphisms in autoimmune diseases A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class II Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide Selector function of MHC I molecules is determined by protein plasticity IMPIPS: the immune protection-inducing protein structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine development Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates.HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis.An unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses.The MHC class II cofactor HLA-DM interacts with Ig in B cells.Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.The melting pot of the MHC II peptidome Dipeptides catalyze rapid peptide exchange on MHC class I molecules HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.Mechanisms of peptide repertoire selection by HLA-DM Recent advances in sortase-catalyzed ligation methodology.The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.HLA-DO and Its Role in MHC Class II Antigen Presentation.Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes.HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.A peptide's perspective on antigen presentation to the immune system.Toward a Network Model of MHC Class II-Restricted Antigen Processing.Inhibition of HLA-DM Mediated MHC Class II Peptide Loading by HLA-DO Promotes Self Tolerance HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.Determinants of immunodominance for CD4 T cells.Peptide and Peptide-Dependent Motions in MHC Proteins: Immunological Implications and Biophysical Underpinnings.Type 1 diabetes associated HLA-DQ2 and DQ8 molecules are relatively resistant to HLA-DM mediated release of invariant chain-derived CLIP peptides Mechanistic understanding and significance of small peptides interaction with MHC class II molecules for therapeutic applications.Present Yourself! By MHC Class I and MHC Class II Molecules.Proofreading of Peptide-MHC Complexes through Dynamic Multivalent Interactions.Peptidomic analysis of type 1 diabetes associated HLA-DQ molecules and the impact of HLA-DM on peptide repertoire editing.Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.The Other Function: Class II-Restricted Antigen Presentation by B Cells.

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Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection

http://www.wikidata.org/entity/Q27675568

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2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Crystal Structure of the HLA-D ...... ms for Rapid Peptide Selection

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Anne-Kathrin Anders

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Dhruv K Sethi

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Jason Pyrdol

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Kai W Wucherpfennig

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Melissa J Call

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Monika-Sarah E D Schulze

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Wouter Pos

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P2860

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

Structure of the human class I histocompatibility antigen, HLA-A2

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules

HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading

Small molecules that enhance the catalytic efficiency of HLA-DM

Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

The Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular Dynamics

Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation

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10.1016/J.CELL.2012.11.025

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23260142

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