SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner
about
A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domainsQuantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complexBinding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAblRegions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligandsThe proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro.Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.Interfacial water molecules in SH3 interactions: Getting the full picture on polyproline recognition by protein-protein interaction domains.Arginine mimetics using α-guanidino acids: introduction of functional groups and stereochemistry adjacent to recognition guanidiniums in peptidesProline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytesApplication of ring-closing metathesis to Grb2 SH3 domain-binding peptides.Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric controlModeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.Proline: the distribution, frequency, positioning, and common functional roles of proline and polyproline sequences in the human proteome.Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.Grb2, a double-edged sword of receptor tyrosine kinase signalingSurvey of the year 2009: applications of isothermal titration calorimetry.Most yeast SH3 domains bind peptide targets with high intrinsic specificity.
P2860
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P2860
SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@ast
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@en
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@en-gb
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@nl
type
label
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@ast
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@en
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@en-gb
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@nl
prefLabel
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@ast
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@en
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@en-gb
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@nl
P2093
P2860
P356
P1433
P1476
SH3 domains of Grb2 adaptor bi ...... actor in a discriminate manner
@en
P2093
Amjad Farooq
Brian J Deegan
Caleb B McDonald
Kenneth L Seldeen
P2860
P304
P356
10.1021/BI802291Y
P407
P577
2009-05-19T00:00:00Z