The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
about
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1A novel proteomic screen for peptide-protein interactionsSelected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptorSH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerSH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR DegradationQuantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complexRegions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligandsSH2- and SH3-mediated interactions between focal adhesion kinase and Src.Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane.Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosisPhosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.Spatio-temporal modeling of signaling protein recruitment to EGFR.Recruitment of the adaptor protein Grb2 to EGFR tetramers.Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactionsModeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.Slow, reversible, coupled folding and binding of the spectrin tetramerization domain.Origins of concentration dependence of waiting times for single-molecule fluorescence bindingPerspective: Dynamics of receptor tyrosine kinase signaling complexesAggregation of membrane proteins by cytosolic cross-linkers: theory and simulation of the LAT-Grb2-SOS1 systemThe adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines.Obtaining and estimating kinetic parameters from the literature.A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling.Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations.Src homology 2 domains enhance tyrosine phosphorylation in vivo by protecting binding sites in their target proteins from dephosphorylation.Quantifying the Interaction between EGFR Dimers and Grb2 in Live Cells.Divalent Cations Differentially Regulate Integrin αIIbCytoplasmic Tail Binding to β3and to Calcium- and Integrin-binding Protein
P2860
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P2860
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
description
1996 nî lūn-bûn
@nan
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@ast
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@en
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@en-gb
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@nl
type
label
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@ast
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@en
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@en-gb
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@nl
prefLabel
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@ast
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@en
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@en-gb
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@nl
P2093
P2860
P921
P356
P1476
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
@en
P2093
P2860
P304
P356
10.1074/JBC.271.48.30472
P407
P577
1996-11-29T00:00:00Z