Regulated association of protein kinase B/Akt with breast tumor kinase
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In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissuesProtein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorPTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestineTNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial CellsLow expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-cateninAn intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Interaction between Brk kinase and insulin receptor substrate-4.Physiological regulation of Akt activity and stability.Brk/PTK6 signaling in normal and cancer cell models.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKMechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancersExpression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFRPTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas.Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancerBrk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR.Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo.Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer.The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation.Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes.Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.Signaling by PTK6PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1PTK6 phosphorylates AKT1Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
P2860
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P2860
Regulated association of protein kinase B/Akt with breast tumor kinase
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Regulated association of protein kinase B/Akt with breast tumor kinase
@ast
Regulated association of protein kinase B/Akt with breast tumor kinase
@en
Regulated association of protein kinase B/Akt with breast tumor kinase
@en-gb
Regulated association of protein kinase B/Akt with breast tumor kinase
@nl
type
label
Regulated association of protein kinase B/Akt with breast tumor kinase
@ast
Regulated association of protein kinase B/Akt with breast tumor kinase
@en
Regulated association of protein kinase B/Akt with breast tumor kinase
@en-gb
Regulated association of protein kinase B/Akt with breast tumor kinase
@nl
prefLabel
Regulated association of protein kinase B/Akt with breast tumor kinase
@ast
Regulated association of protein kinase B/Akt with breast tumor kinase
@en
Regulated association of protein kinase B/Akt with breast tumor kinase
@en-gb
Regulated association of protein kinase B/Akt with breast tumor kinase
@nl
P2093
P2860
P3181
P356
P1476
Regulated association of protein kinase B/Akt with breast tumor kinase
@en
P2093
Abby Olsen
Carol A Lange
Daniel Fitzsimmons
Emily J Faivre
Julie Hanson Ostrander
Ping Zhang
P2860
P304
P3181
P356
10.1074/JBC.M412038200
P407
P577
2005-01-21T00:00:00Z