Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency
about
Targeting BCL2-Proteins for the Treatment of Solid TumoursStrategic applications of gene expression: from drug discovery/development to bedsideApoptotic agentsDiscovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based DesignDiscovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based designAlternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem CellsA Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.Systematic assessment of analytical methods for drug sensitivity prediction from cancer cell line dataVirtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance.Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.Drug susceptibility prediction against a panel of drugs using kernelized Bayesian multitask learningMaturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer.BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells.Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines.Wnt modulates MCL1 to control cell survival in triple negative breast cancer.Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling.Rapamycin rescues ABT-737 efficacy in small cell lung cancerSynergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain.Bcl-xL controls a switch between cell death modes during mitotic arrestmiR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies.miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family membersMyeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer.Thymoma patients treated in a phase I clinic at MD Anderson Cancer Center: responses to mTOR inhibitors and molecular analyses.Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular ModelsCritical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death.Apoptosis and necrosis in the liverTargeting SOD1 reduces experimental non–small-cell lung cancerIntegrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survivalProfiling of ileal carcinoids.Biomarkers of therapeutic response to BCL2 antagonists in cancer.Programming cancer cells for high expression levels of Mcl1.Evading apoptosis in cancer.Small molecule Mcl-1 inhibitors for the treatment of cancer.
P2860
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P2860
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@ast
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@en
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@en-gb
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@nl
type
label
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@ast
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@en
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@en-gb
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@nl
prefLabel
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@ast
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@en
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@en-gb
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@nl
P2093
P2860
P3181
P1433
P1476
Chemical genomics identifies s ...... a predictor of MCL1 dependency
@en
P2093
Adam A Margolin
Andrew L Kung
Bina Julian
Emily Brown
Leila Haery
Lisa Cucolo
Rameen Beroukhim
Shyemaa Shehata
Todd R Golub
P2860
P304
P3181
P356
10.1016/J.CCR.2012.02.028
P407
P577
2012-04-17T00:00:00Z