Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
about
Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactionsStructural Re-engineering of the α-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1-Bak-BH3 Protein-Protein Interaction with 2,6-Di-Substituted NicotinatesKilling Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation.Moderate endoplasmic reticulum stress activates a PERK and p38-dependent apoptosis.The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases.hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.Resistance to Cell Death and Its Modulation in Cancer Stem Cells.Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cellsDirectly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.Designing helical peptide inhibitors of protein-protein interactionsDeorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide.The contribution of the programmed cell death machinery in innate immune cells to lupus nephritis.RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment.YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer.Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells.Pyrrolidine dithiocarbamate sensitizes U251 brain glioma cells to temozolomide via downregulation of MGMT and BCL-XL.50 years of The FEBS Journal: looking back as well as ahead.Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.Special Issue on Cell Death: Murder, mystery (and a little bit of mayhem) in Manhattan.Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia.ShDcR3 sensitizes TRAIL-resistant HCC cells by inducing caspase-dependent apoptosis while suppressing NF-κB dependent cFLIPL expression.A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells.Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection?Bax retrotranslocation potentiates Bcl-xL's antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance.HDAC and Ku70 axis- an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue.BFL-1 expression determines the efficacy of venetoclax in MYC+/BCL2+ double hit lymphoma.HCMV Infection and Apoptosis: How Do Monocytes Survive HCMV Infection?Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers
P2860
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P2860
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
@ast
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
@en
type
label
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
@ast
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
@en
prefLabel
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
@ast
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
@en
P2860
P356
P1433
P1476
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
@en
P2093
Joseph T Opferman
P2860
P304
P356
10.1111/FEBS.13472
P407
P577
2015-08-21T00:00:00Z