about
Reconstruction of ancestral protein sequences and its applicationsM-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHpCharacterization of GFR, a novel guanine nucleotide exchange factor for Rap1RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humansPDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase RalRegulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factorIdentification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interactionA crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleedingStructural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6KCatalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanismOligomerization of DH domain is essential for Dbl-induced transformationSpecificity in Ras and Rap signalingGrb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1The Dictyostelium genome encodes numerous RasGEFs with multiple biological rolesRegulation of small GTPases by GEFs, GAPs, and GDIsFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityRational design of small molecule inhibitors targeting the Ras GEF, SOS1.Structure of the small G protein Rap2 in a non-catalytic complex with GTPAn open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanismStructure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules.The structural basis for the transition from Ras-GTP to Ras-GDPStructure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residueA Catalytic Coiled Coil: Structural Insights into the Activation of the Rab GTPase Sec4p by Sec2pMolecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor ProteinThe Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes3D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reactionStructure of ERA in complex with the 3' end of 16S rRNA: Implications for ribosome biogenesisActivation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensorStructure of the Dominant Negative S17N Mutant of Ras ,Role of the histone domain in the autoinhibition and activation of the Ras activator Son of SevenlessMagnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutSAllosteric modulation of Ras positions Q61 for a direct role in catalysis
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The structural basis of the activation of Ras by Sos
@ast
The structural basis of the activation of Ras by Sos
@en
The structural basis of the activation of Ras by Sos
@en-gb
The structural basis of the activation of Ras by Sos
@nl
type
label
The structural basis of the activation of Ras by Sos
@ast
The structural basis of the activation of Ras by Sos
@en
The structural basis of the activation of Ras by Sos
@en-gb
The structural basis of the activation of Ras by Sos
@nl
prefLabel
The structural basis of the activation of Ras by Sos
@ast
The structural basis of the activation of Ras by Sos
@en
The structural basis of the activation of Ras by Sos
@en-gb
The structural basis of the activation of Ras by Sos
@nl
P2093
P3181
P356
P1433
P1476
The structural basis of the activation of Ras by Sos
@en
P2093
D Bar-Sagi
P A Boriack-Sjodin
S M Margarit
P2888
P304
P3181
P356
10.1038/28548
P407
P577
1998-07-23T00:00:00Z
P6179
1021391978